A Multi-Pronged Approach Targeting SARS-CoV-2 Proteins Using Ultra-Large Virtual Screening.
ACE2
COVID-19 data
In silico
MPro
NSP16/NSP10
PLpro inhibitors
RdRP
SARS-CoV -2
SARS-CoV2 Small molecule inhibitor
Spike
TMPRSS2
computational biology
drug discovery
nsp10
nsp13
nsp14-exonuclease
nsp16
nsp3 macrdomain
nsp5
nsp7
nsp8
nsp9
nucleoprotein
virtual screening
Journal
ChemRxiv : the preprint server for chemistry
ISSN: 2573-2293
Titre abrégé: ChemRxiv
Pays: United States
ID NLM: 101720906
Informations de publication
Date de publication:
24 Jul 2020
24 Jul 2020
Historique:
revised:
24
07
2020
entrez:
17
11
2020
pubmed:
18
11
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 novel coronavirus (2019-nCoV), has spread rapidly across the globe, creating an unparalleled global health burden and spurring a deepening economic crisis. As of July 7th, 2020, almost seven months into the outbreak, there are no approved vaccines and few treatments available. Developing drugs that target multiple points in the viral life cycle could serve as a strategy to tackle the current as well as future coronavirus pandemics. Here we leverage the power of our recently developed
Identifiants
pubmed: 33200116
doi: 10.26434/chemrxiv.12682316
pii: 12682316
pmc: PMC7668741
doi:
Types de publication
Preprint
Langues
eng
Commentaires et corrections
Type : UpdateIn
Déclaration de conflit d'intérêts
Alexander Chuprina, Dmytro Radchenko, and Iryna Iavniuk work for Enamine, Kyiv Ukraine. Igor Dziuba works for UkrOrgSyntez Ltd, Kyiv Ukraine. Olga Tarkhanova, Alla Plekhova, and Yurii Moroz work for Chemspace Kyiv, Ukraine. Enamine, UkrOrgSyntez, and Chemspace are companies that are involved in the synthesis and distribution of drug-like compounds. Yurii Moroz is a scientific advisor for Enamine.
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