Neuraminidase inhibitors rewire neutrophil function

COVID-19 Oseltamivir SARS-CoV-2 Zanamivir neuraminidase neutrophil sepsis sialic acid

Journal

bioRxiv : the preprint server for biology
Titre abrégé: bioRxiv
Pays: United States
ID NLM: 101680187

Informations de publication

Date de publication:
14 Oct 2022
Historique:
pubmed: 18 11 2020
medline: 18 11 2020
entrez: 17 11 2020
Statut: epublish

Résumé

Neutrophil overstimulation plays a crucial role in tissue damage during severe infections. Neuraminidase (NEU)-mediated cleavage of surface sialic acid has been demonstrated to regulate leukocyte responses. Here, we report that antiviral NEU inhibitors constrain host NEU activity, surface sialic acid release, ROS production, and NETs released by microbial-activated human neutrophils.

Identifiants

DOI: 10.1101/2020.11.12.379115 PMID: 33200130 PMC: PMC7668734
pubmed: 33200130
doi: 10.1101/2020.11.12.379115
pmc: PMC7668734
pii:
doi:

Types de publication

Preprint

Langues

eng

Subventions

Organisme : FIC NIH HHS
ID : R01 TW008276
Pays : United States

Déclaration de conflit d'intérêts

Competing Interests statement The authors declare that no conflict of interest exists.

Auteurs

Rodrigo de Oliveira Formiga (R)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Flávia C Amaral (FC)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Camila F Souza (CF)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Daniel A G B Mendes (DAGB)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Carlos W S Wanderley (CWS)

Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Cristina B Lorenzini (CB)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Adara A Santos (AA)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Juliana Antônia (J)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Lucas F Faria (LF)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Caio C Natale (CC)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Nicholas M Paula (NM)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Priscila C S Silva (PCS)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Fernanda R Fonseca (FR)

Department of Clinical Medicine, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Luan Aires (L)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Nicoli Heck (N)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Márick R Starick (MR)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Celso M Queiroz-Junior (CM)

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Felipe R S Santos (FRS)

Department of Biochemistry and Immunology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Filipe R O de Souza (FRO)

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Vivian V Costa (VV)

Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.

Shana P C Barroso (SPC)

Molecular Biology Laboratory, Institute of Biomedical Research, Marcilio Dias Naval Hospital, Navy of Brazil, RJ, Brazil.

Alexandre Morrot (A)

Tuberculosis Research Laboratory, Faculty of Medicine, Federal University of Rio de Janeiro.
Immunoparasitology Laboratory, Oswaldo Cruz Foundation, FIOCRUZ, Rio de Janeiro, Brazil.

Johan Van Weyenbergh (J)

Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory for Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium.

Regina Sordi (R)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Frederico Alisson-Silva (F)

Department of Immunology, Paulo de Goes Institute of Microbiology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Fernando Q Cunha (FQ)

Department of Pharmacology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, SP, Brazil.

Edroaldo L Rocha (EL)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Sylvie Chollet-Martin (S)

INSERM UMR 996, "Infammation, Microbiome and Immunosurveillance", Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France.

Maria Margarita Hurtado-Nedelec (MM)

INSERM-U1149, Faculté de Médecine, Site Xavier Bichat, CNRS, Université de Paris, Paris, France.

Clémence Martin (C)

Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.
Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France.

Pierre-Régis Burgel (PR)

Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.
Department of Pneumology, AP-HP, Hôpital Cochin, Paris, France.

Daniel S Mansur (DS)

Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Rosemeri Maurici (R)

Department of Clinical Medicine, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Matthew S Macauley (MS)

Department of Chemistry, Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada.

André Báfica (A)

Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Véronique Witko-Sarsat (V)

Université de Paris, Institut Cochin, INSERM U1016, CNRS, Paris, France.

Fernando Spiller (F)

Department of Pharmacology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.
Laboratory of Immunobiology, Department of Microbiology, Immunology and Parasitology, Federal University of Santa Catarina, Florianopolis, SC, Brazil.

Classifications MeSH