Mechanisms and consequences of dysregulation of the Tiam family of Rac activators in disease.

Animals Cell Adhesion Cell Movement Cell Proliferation Cell Survival Guanine Nucleotide Exchange Factors / metabolism Humans Immune System Neoplasms / metabolism Nervous System Diseases / metabolism Neurons / metabolism Protein Domains RNA Processing, Post-Transcriptional Signal Transduction T-Lymphoma Invasion and Metastasis-inducing Protein 1 / metabolism rac GTP-Binding Proteins / metabolism rac1 GTP-Binding Protein / metabolism
Rac Tiam1/STEF cancer guanine nucleotide exchange factor molecular basis of health and disease

Journal

Biochemical Society transactions
ISSN: 1470-8752
Titre abrégé: Biochem Soc Trans
Pays: England
ID NLM: 7506897

Informations de publication

Date de publication:
18 12 2020
Historique:
received: 01 09 2020
revised: 16 10 2020
accepted: 16 10 2020
pubmed: 18 11 2020
medline: 10 8 2021
entrez: 17 11 2020
Statut: ppublish

Résumé

The Tiam family proteins - Tiam1 and Tiam2/STEF - are Rac1-specific Guanine Nucleotide Exchange Factors (GEFs) with important functions in epithelial, neuronal, immune and other cell types. Tiam GEFs regulate cellular migration, proliferation and survival, mainly through activating and directing Rac1 signalling. Dysregulation of the Tiam GEFs is significantly associated with human diseases including cancer, immunological and neurological disorders. Uncovering the mechanisms and consequences of dysregulation is therefore imperative to improving the diagnosis and treatment of diseases. Here we compare and contrast the subcellular localisation and function of Tiam1 and Tiam2/STEF, and review the evidence for their dysregulation in disease.

Identifiants

DOI: 10.1042/BST20200481 PMID: 33200195
pubmed: 33200195
pii: 226971
doi: 10.1042/BST20200481
doi:

Substances chimiques

Guanine Nucleotide Exchange Factors 0
T-Lymphoma Invasion and Metastasis-inducing Protein 1 0
TIAM1 protein, human 0
TIAM2 protein, human 0
rac GTP-Binding Proteins EC 3.6.5.2
rac1 GTP-Binding Protein EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2703-2719

Subventions

Organisme : Cancer Research UK
ID : C5759/A20410
Pays : United Kingdom

Informations de copyright

© 2020 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

Auteurs

Joe Maltas (J)

Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.

Hannah Reed (H)

Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.

Andrew Porter (A)

Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.

Angeliki Malliri (A)

Cell Signalling Group, Cancer Research UK Manchester Institute, The University of Manchester, Alderley Park SK10 4TG, U.K.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Adhérence cellulaire › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Tumeurs › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Maladies du système nerveux › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Cellules › Neurones › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Conformation moléculaire › Conformation des protéines › Structure tertiaire des protéines › Domaines protéiques › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Maturation post-transcriptionnelle des ARN › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Régulateurs des protéines G › Facteurs d'échange de nucléotides guanyliques › Protéine-1 de lymphome-T induisant l'invasion et les metastases › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéines G rac › Mechanisms and consequences of dysregulation...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines G › Protéines G monomériques › Protéines G rho › Protéines G rac › Protéine G rac1 › Mechanisms and consequences of dysregulation...