Insights into the molecular pathogenesis of ocular tuberculosis.
Autoimmunity
Histopathology
Immunopathogenesis
Molecular mimicry
Mycobacterium tuberculosis
Ocular tuberculosis
Retinal pigment epithelium (RPE)
Journal
Tuberculosis (Edinburgh, Scotland)
ISSN: 1873-281X
Titre abrégé: Tuberculosis (Edinb)
Pays: Scotland
ID NLM: 100971555
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
21
09
2020
revised:
02
11
2020
accepted:
04
11
2020
pubmed:
18
11
2020
medline:
4
11
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
Unclear pathogenic mechanisms underlying the ocular tuberculosis (OTB) has resulted in perplexity related to the diagnosis and management of the disease. Developments in experimental research and innovations in molecular diagnostics have recently provided a new understanding of disease pathogenesis and natural history. The current review focuses on the new insights into OTB pathogenesis, derived from in vivo and in vitro studies on Mycobacterium tuberculosis dissemination and localization into the eye, in combination with histopathological studies on chorioretinal tissue and vascular network. Advances in the knowledge of OTB have influenced disease management in the clinical setting and lead to reconsideration of the role of existing treatments and suggesting potential new therapeutic approaches.
Identifiants
pubmed: 33202350
pii: S1472-9792(20)30185-2
doi: 10.1016/j.tube.2020.102018
pii:
doi:
Substances chimiques
Antibodies, Bacterial
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102018Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.