Impaired Platelet Function in Sept8-Deficient Mice In Vitro.
Animals
Blood Platelets
/ drug effects
Crotalid Venoms
/ pharmacology
Cytoplasmic Granules
/ drug effects
Exocytosis
Female
Fibrinogen
/ metabolism
Genotype
Lectins, C-Type
Lysosomes
/ metabolism
Mice, Inbred C57BL
Mice, Knockout
Phenotype
Platelet Activation
/ drug effects
Platelet Aggregation
Platelet Glycoprotein GPIIb-IIIa Complex
/ metabolism
Septins
/ blood
Thrombin
/ metabolism
Journal
Thrombosis and haemostasis
ISSN: 2567-689X
Titre abrégé: Thromb Haemost
Pays: Germany
ID NLM: 7608063
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
pubmed:
18
11
2020
medline:
16
11
2021
entrez:
17
11
2020
Statut:
ppublish
Résumé
Septins (Septs) are a widely expressed protein family of 13 mammalian members, recognized as a unique component of the cytoskeleton. In human platelets, we previously described that SEPT4 and SEPT8 are localized surrounding α-granules and move to the platelet surface after activation, indicating a possible role in platelet physiology. In this study, we investigated the impact of Sept8 on platelet function
Identifiants
pubmed: 33202444
doi: 10.1055/s-0040-1718733
doi:
Substances chimiques
Crotalid Venoms
0
Lectins, C-Type
0
Platelet Glycoprotein GPIIb-IIIa Complex
0
SEPT8 protein, mouse
0
convulxin
37206-04-5
Fibrinogen
9001-32-5
Thrombin
EC 3.4.21.5
Septins
EC 3.6.1.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
484-494Subventions
Organisme : ZI 486/4-1
ID : Deutsche Forschungsgemeinschaft DFG
Organisme : ZI 486/8-1
ID : Deutsche Forschungsgemeinschaft DFG
Organisme : BMBF 01EO1503
ID : German Federal Ministry of Education and Research
Informations de copyright
Thieme. All rights reserved.
Déclaration de conflit d'intérêts
None declared.