Increased Prevalence of Liver Fibrosis and HIV Viremia among Patients with HIV, HBV, and Tuberculosis in Botswana.

Africa Botswana hepatitis B virus human immunodeficiency virus tuberculosis

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
14 Nov 2020
Historique:
received: 08 10 2020
revised: 11 11 2020
accepted: 11 11 2020
entrez: 18 11 2020
pubmed: 19 11 2020
medline: 19 11 2020
Statut: epublish

Résumé

People with concomitant human immunodeficiency virus (HIV) and tuberculosis (TB) have an increased risk of hepatotoxic reactions due to antiretroviral therapy (ART) and anti-TB therapy (ATT). Concomitant hepatitis B virus (HBV) in these patients may lead to poorer health outcomes. To assess liver enzyme levels and immune response in adults with HIV, HBV, and TB, data from 300 antiretroviral-naïve people living with HIV (PLWHIV) were analyzed. The prevalence of HIV/HBV (cHIV/HBV) and HIV/TB (cHIV/TB) was 28% (95% CI: 23.0-33.4) and 10% (95% CI: 6.8-14.0), respectively. HIV/HBV/TB (cHIV/HBV/TB) prevalence was 5.3% (95% CI: 3.1-8.5). There was a statistically significant difference between the groups of participants in HIV viral load (

Identifiants

pubmed: 33202597
pii: pathogens9110950
doi: 10.3390/pathogens9110950
pmc: PMC7696587
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Wellcome Trust
ID : 218770/Z/19/Z
Pays : United Kingdom
Organisme : Sub-Saharan African Network for TB/HIV Research Excellence (SANTHE)
ID : DEL-15-006
Organisme : H3ABioNet
ID : U41HG006941

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Auteurs

Bonolo B Phinius (BB)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Motswedi Anderson (M)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Lynnette Bhebhe (L)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Kabo Baruti (K)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Biological Sciences, Faculty of Sciences, University of Botswana, Gaborone 0000, Botswana.

Godiraone Manowe (G)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Wonderful T Choga (WT)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

Lucy Mupfumi (L)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.

Tshepiso Mbangiwa (T)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Pathology, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa.

Mbatshi Mudanga (M)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Statistics, Faculty of Sciences, University of Botswana, Gaborone 0000, Botswana.

Sikhulile Moyo (S)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Richard Marlink (R)

Rutgers Global Health Institute, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ 08901, USA.

Jason T Blackard (JT)

Division of Digestive Diseases, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

Simani Gaseitsiwe (S)

Research Laboratory, Botswana Harvard AIDS Institute Partnership, Gaborone 0000, Botswana.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA.

Classifications MeSH