Efficacy and Toxicity of Different Chemotherapy Protocols for Concurrent Chemoradiation in Non-Small Cell Lung Cancer-A Secondary Analysis of the PET Plan Trial.

NSCLC chemoradiotherapy concomitant chemoradiation non-small cell lung cancer

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
13 Nov 2020
Historique:
received: 03 10 2020
revised: 01 11 2020
accepted: 05 11 2020
entrez: 18 11 2020
pubmed: 19 11 2020
medline: 19 11 2020
Statut: epublish

Résumé

(1) Background: The optimal chemotherapy (CHT) regimen for concurrent chemoradiation (cCRT) is not well defined. In this secondary analysis of the international randomized PET-Plan trial, we evaluate the efficacy of different CHT. (2) Methods: Patients with inoperable NSCLC were randomized at a 1:1 ratio regarding the target volume definition and received isotoxically dose-escalated cCRT using cisplatin 80 mg/m

Identifiants

pubmed: 33202825
pii: cancers12113359
doi: 10.3390/cancers12113359
pmc: PMC7697287
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Eleni Gkika (E)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Stefan Lenz (S)

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, 79106 Freiburg, Germany.

Tanja Schimek-Jasch (T)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Cornelius F Waller (CF)

Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Department of Medicine I, Hematology, Oncology and Stem Cell Transplantation, Medical Center-University of Freiburg, 79106 Freiburg, Germany.

Stephanie Kremp (S)

Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center and Faculty of Medicine, 66421 Homburg/Saar, Germany.

Andrea Schaefer-Schuler (A)

Department of Nuclear Medicine, Saarland University Medical Center and Faculty of Medicine, 66421 Homburg/Saar, Germany.

Michael Mix (M)

Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Department of Nuclear Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.

Andreas Küsters (A)

Department of Radiation Oncology, Kliniken Maria Hilf, 41063 Mönchengladbach, Germany.

Marco Tosch (M)

Department of Nuclear Medicine, Helios University Hospital Wuppertal, 42283 Wuppertal, Germany.
Department of Medicine, Faculty of Health, University of Witten/Herdecke, 58448 Witten, Germany.

Thomas Hehr (T)

Department of Radiation Oncology, Marienhospital, 70199 Stuttgart, Germany.

Susanne Martina Eschmann (SM)

Department of Nuclear Medicine, Marienhospital, 70199 Stuttgart, Germany.

Yves-Pierre Bultel (YP)

Department of Radiation Oncology, Klinikum Mutterhaus der Boromäerinnen, 54290 Trier, Germany.

Peter Hass (P)

Department of Radiation Oncology, University Hospital Magdeburg, 39120 Magdeburg, Germany.

Jochen Fleckenstein (J)

Department of Radiotherapy and Radiation Oncology, Saarland University Medical Center and Faculty of Medicine, 66421 Homburg/Saar, Germany.

Alexander Henry Thieme (AH)

Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, 13353 Berlin, Germany.

Marcus Stockinger (M)

Department of Radiation Oncology, University Hospital Mainz, 55131 Mainz, Germany.

Karin Dieckmann (K)

Department of Radiotherapy, Vienna General Hospital, Medical University of Vienna, 1090 Vienna, Austria.

Matthias Miederer (M)

Department of Nuclear Medicine, University Hospital Mainz, 55131 Mainz, Germany.

Gabriele Holl (G)

Department of Nuclear Medicine, Kliniken Schwerin, 19055 Schwerin, Germany.

Hans Christian Rischke (HC)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Department of Nuclear Medicine, Medical Center-University of Freiburg, 79106 Freiburg, Germany.

Sonja Adebahr (S)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Jochem König (J)

Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Hospital of Mainz, 55131 Mainz, Germany.

Harald Binder (H)

Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, 79106 Freiburg, Germany.

Anca-Ligia Grosu (AL)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Ursula Nestle (U)

Department of Radiation Oncology, Medical Center-University of Freiburg, Robert-Koch-Str. 3, 79106 Freiburg, Germany.
German Cancer Consortium (DKTK) Partner Site Freiburg, German Cancer Research Center (DKFZ), Neuenheimer Feld 280, 69120 Heidelberg, Germany.
Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Department of Radiation Oncology, Kliniken Maria Hilf, 41063 Mönchengladbach, Germany.

Classifications MeSH