Nano Carrier Drug Delivery Systems for the Treatment of Neuropsychiatric Disorders: Advantages and Limitations.
Alzheimer Disease
/ drug therapy
Amyloid beta-Protein Precursor
/ chemistry
Animals
Anti-Anxiety Agents
/ administration & dosage
Antidepressive Agents
/ administration & dosage
Antipsychotic Agents
/ administration & dosage
Anxiety Disorders
/ drug therapy
Bipolar Disorder
/ drug therapy
Blood-Brain Barrier
/ drug effects
Depression
/ drug therapy
Drug Carriers
/ chemistry
Drug Delivery Systems
Drug Design
Emulsions
/ chemistry
Humans
Lipids
/ chemistry
Nanoparticles
/ chemistry
Neurons
/ drug effects
Neuroprotective Agents
/ administration & dosage
Permeability
Polymers
/ chemistry
Schizophrenia
/ drug therapy
tau Proteins
/ chemistry
Alzheimer’s disease
BBB
anxiety
bipolar disorder
depression
nanocarriers
schizophrenia
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
13 Nov 2020
13 Nov 2020
Historique:
received:
20
10
2020
revised:
09
11
2020
accepted:
11
11
2020
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
10
4
2021
Statut:
epublish
Résumé
Neuropsychiatric diseases are one of the main causes of disability, affecting millions of people. Various drugs are used for its treatment, although no effective therapy has been found yet. The blood brain barrier (BBB) significantly complicates drugs delivery to the target cells in the brain tissues. One of the problem-solving methods is the usage of nanocontainer systems. In this review we summarized the data about nanoparticles drug delivery systems and their application for the treatment of neuropsychiatric disorders. Firstly, we described and characterized types of nanocarriers: inorganic nanoparticles, polymeric and lipid nanocarriers, their advantages and disadvantages. We discussed ways to interact with nerve tissue and methods of BBB penetration. We provided a summary of nanotechnology-based pharmacotherapy of schizophrenia, bipolar disorder, depression, anxiety disorder and Alzheimer's disease, where development of nanocontainer drugs derives the most active. We described various experimental drugs for the treatment of Alzheimer's disease that include vector nanocontainers targeted on β-amyloid or tau-protein. Integrally, nanoparticles can substantially improve the drug delivery as its implication can increase BBB permeability, the pharmacodynamics and bioavailability of applied drugs. Thus, nanotechnology is anticipated to overcome the limitations of existing pharmacotherapy of psychiatric disorders and to effectively combine various treatment modalities in that direction.
Identifiants
pubmed: 33202839
pii: molecules25225294
doi: 10.3390/molecules25225294
pmc: PMC7697162
pii:
doi:
Substances chimiques
APP protein, human
0
Amyloid beta-Protein Precursor
0
Anti-Anxiety Agents
0
Antidepressive Agents
0
Antipsychotic Agents
0
Drug Carriers
0
Emulsions
0
Lipids
0
MAPT protein, human
0
Neuroprotective Agents
0
Polymers
0
tau Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of Russian Federation
ID : № 075-15-2020-792 (Unique identifier RF----190220X0031)
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