[Advances in Molecular Biomarker for Pulmonary Large Cell Neuroendocrine Carcinoma].
Diagnostic-related marker
Molecular subtype
Prognostic-related marker
Pulmonary large cell neuroendocrine carcinoma
Journal
Zhongguo fei ai za zhi = Chinese journal of lung cancer
ISSN: 1999-6187
Titre abrégé: Zhongguo Fei Ai Za Zhi
Pays: China
ID NLM: 101126433
Informations de publication
Date de publication:
20 Nov 2020
20 Nov 2020
Historique:
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
3
8
2021
Statut:
ppublish
Résumé
Pulmonary large cell neuroendocrine carcinoma (LCNEC) is a pathological subtype of lung neuroendocrine cancer, which accounts for 2.4%-3.1% in surgical specimens of lung cancer. It is characterized by high invasiveness and poor prognosis, and highly correlated with smoking. There are few relevant studies due to the low incidence and small sample size. Therefore, it is relatively difficult to diagnosis and treatment in clinical practice. In this review, we described molecular subtype, diagnostic and prognostic-related markers about large cell neuroendocrine carcinoma of lung based on the recent progress in genomic sequencing and molecular markers, to find the direction for the next research.
. 【中文题目：肺大细胞神经内分泌癌分子标志物的
研究进展】 【中文摘要：肺大细胞神经内分泌癌（pulmonary large cell neuroendocrine carcinoma, LCNEC）为肺神经内分泌癌的一种病理亚型，其发病率占肺癌手术标本的2.4%-3.1%，具有侵袭性高、预后差的特点，与吸烟高度相关。因发病率低、样本量少的原因导致相关研究较少，因此在临床上对肺LCNEC的诊断及治疗相对困难。本文结合近年肺大细胞神经内分泌癌相关基因测序及分子标志物的研究进展，对其分子分型、诊断及预后相关生物标志物进行阐述，为下一步研究方案寻找方向。
】 【中文关键词：肺大细胞神经内分泌癌；分子分型；诊断相关标志物；预后相关标志物】.
Autres résumés
Type: Publisher
(chi)
【中文题目：肺大细胞神经内分泌癌分子标志物的
研究进展】 【中文摘要：肺大细胞神经内分泌癌（pulmonary large cell neuroendocrine carcinoma, LCNEC）为肺神经内分泌癌的一种病理亚型，其发病率占肺癌手术标本的2.4%-3.1%，具有侵袭性高、预后差的特点，与吸烟高度相关。因发病率低、样本量少的原因导致相关研究较少，因此在临床上对肺LCNEC的诊断及治疗相对困难。本文结合近年肺大细胞神经内分泌癌相关基因测序及分子标志物的研究进展，对其分子分型、诊断及预后相关生物标志物进行阐述，为下一步研究方案寻找方向。
】 【中文关键词：肺大细胞神经内分泌癌；分子分型；诊断相关标志物；预后相关标志物】.
Identifiants
pubmed: 33203199
doi: 10.3779/j.issn.1009-3419.2020.101.46
pmc: PMC7679220
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
chi
Sous-ensembles de citation
IM
Pagination
983-988Références
Thorac Cancer. 2020 Jul;11(7):2036-2039
pubmed: 32379390
Nat Commun. 2014 Mar 27;5:3518
pubmed: 24670920
Ann Oncol. 2015 Aug;26(8):1604-20
pubmed: 25646366
Transl Lung Cancer Res. 2017 Oct;6(5):530-539
pubmed: 29114469
Br J Surg. 2000 Aug;87(8):992-1005
pubmed: 10931041
Lancet. 2017 Jan 21;389(10066):255-265
pubmed: 27979383
Lung Cancer. 2018 May;119:48-55
pubmed: 29656752
Clin Cancer Res. 2018 Jan 1;24(1):33-42
pubmed: 29066508
Transl Lung Cancer Res. 2020 Feb;9(1):45-54
pubmed: 32206552
Dev Biol. 2009 Apr 15;328(2):529-40
pubmed: 19389376
J Thorac Oncol. 2015 Sep;10(9):1240-1242
pubmed: 26291007
Nat Rev Cancer. 2013 Apr;13(4):246-57
pubmed: 23467301
Cancer Lett. 2004 Feb 20;204(2):159-69
pubmed: 15013215
Clin Cancer Res. 2020 Feb 15;26(4):892-901
pubmed: 31694833
J Pathol. 2017 Mar;241(4):488-500
pubmed: 27873319
Lung Cancer. 2020 May;143:40-46
pubmed: 32203769
Arch Med Sci. 2019 Jul;15(4):1010-1016
pubmed: 31360195
Int J Oncol. 2017 Sep;51(3):781-790
pubmed: 28766688
J Cancer Res Clin Oncol. 2015 Dec;141(12):2121-30
pubmed: 25963795
Hum Pathol. 2016 Feb;48:142-7
pubmed: 26596584
Lung Cancer. 2019 Dec;138:102-108
pubmed: 31678831
Cancer Sci. 2016 Oct;107(10):1527-1538
pubmed: 27418196
Clin Cancer Res. 2017 Feb 1;23(3):757-765
pubmed: 27507618
Cell. 1996 Feb 23;84(4):623-31
pubmed: 8598048
Oncotarget. 2016 Nov 29;7(48):78994-79007
pubmed: 27806343
Gen Thorac Cardiovasc Surg. 2017 Nov;65(11):633-639
pubmed: 28766133
Pathol Oncol Res. 1999;5(3):179-86
pubmed: 10491014
Arch Pathol Lab Med. 2013 May;137(5):668-84
pubmed: 22970842
Hum Mutat. 2008 May;29(5):609-16
pubmed: 18293376
J Lifestyle Med. 2015 Mar;5(1):1-6
pubmed: 26528423
Histopathology. 2014 Mar;64(4):547-56
pubmed: 24266897
N Engl J Med. 2016 Nov 10;375(19):1823-1833
pubmed: 27718847
Biochim Biophys Acta. 1994 May 27;1198(1):11-26
pubmed: 8199193
Hum Pathol. 2004 Sep;35(9):1148-55
pubmed: 15343518
Diagn Cytopathol. 2011 Mar;39(3):159-67
pubmed: 21319315
Oncotarget. 2015 Sep 8;6(26):22028-37
pubmed: 26124082
Ther Adv Med Oncol. 2020 Jul 7;12:1758835920937972
pubmed: 32684990
Cancer. 2001 Jun 1;91(11):1992-2000
pubmed: 11391577
J Cell Sci. 1994 Dec;107 ( Pt 12):3655-63
pubmed: 7706414
Clin Cancer Res. 2016 Jul 15;22(14):3618-29
pubmed: 26960398
J Thorac Cardiovasc Surg. 2002 Aug;124(2):285-92
pubmed: 12167788
Endocr Pathol. 2003 Summer;14(2):133-9
pubmed: 12858003
Ann Thorac Surg. 2019 Jul;108(1):235-243
pubmed: 30910656
Arch Med Sci. 2016 Feb 1;12(1):222-6
pubmed: 26925141
J Thorac Oncol. 2015 Aug;10(8):1133-41
pubmed: 26039012
Int J Cancer. 2016 Feb 15;138(4):927-38
pubmed: 26340530
Cancer Res. 2009 Feb 1;69(3):845-54
pubmed: 19176379
Nat Commun. 2018 Mar 13;9(1):1048
pubmed: 29535388