Young adult-born neurons improve odor coding by mitral cells.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
17 11 2020
17 11 2020
Historique:
received:
01
12
2019
accepted:
28
09
2020
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
17
12
2020
Statut:
epublish
Résumé
New neurons are continuously generated in the adult brain through a process called adult neurogenesis. This form of plasticity has been correlated with numerous behavioral and cognitive phenomena, but it remains unclear if and how adult-born neurons (abNs) contribute to mature neural circuits. We established a highly specific and efficient experimental system to target abNs for causal manipulations. Using this system with chemogenetics and imaging, we found that abNs effectively sharpen mitral cells (MCs) tuning and improve their power to discriminate among odors. The effects on MCs responses peaked when abNs were young and decreased as they matured. To explain the mechanism of our observations, we simulated the olfactory bulb circuit by modelling the incorporation of abNs into the circuit. We show that higher excitability and broad input connectivity, two well-characterized features of young neurons, underlie their unique ability to boost circuit computation.
Identifiants
pubmed: 33203831
doi: 10.1038/s41467-020-19472-8
pii: 10.1038/s41467-020-19472-8
pmc: PMC7673122
doi:
Substances chimiques
Tamoxifen
094ZI81Y45
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
5867Références
Nature. 2004 May 13;429(6988):184-7
pubmed: 15107864
Curr Opin Neurobiol. 2005 Feb;15(1):121-8
pubmed: 15721754
J Neurosci. 2004 Apr 14;24(15):3726-35
pubmed: 15084652
Neuron. 2012 Dec 6;76(5):962-75
pubmed: 23217744
Proc Natl Acad Sci U S A. 2011 May 17;108(20):8479-84
pubmed: 21536899
Eur J Neurosci. 2006 Dec;24(12):3578-88
pubmed: 17229106
Hum Gene Ther. 2006 Jun;17(6):635-50
pubmed: 16776572
Nat Neurosci. 2007 Apr;10(4):444-52
pubmed: 17369823
Sci Rep. 2018 Mar 9;8(1):4311
pubmed: 29523815
Science. 1997 Apr 4;276(5309):66-71
pubmed: 9082987
Nat Neurosci. 2008 Oct;11(10):1153-61
pubmed: 18758458
Nat Rev Neurosci. 2006 Mar;7(3):179-93
pubmed: 16495940
Nat Commun. 2018 Feb 28;9(1):871
pubmed: 29491360
Science. 2012 Mar 9;335(6073):1238-42
pubmed: 22282476
J Neurosci. 2007 Oct 3;27(40):10906-11
pubmed: 17913924
Hippocampus. 2012 Feb;22(2):292-8
pubmed: 21049483
Nat Neurosci. 1999 Mar;2(3):266-70
pubmed: 10195220
Phys Rev Lett. 2001 May 21;86(21):4958-61
pubmed: 11384391
Science. 1994 May 20;264(5162):1145-8
pubmed: 8178174
J Neurosci. 2016 Aug 24;36(34):8856-71
pubmed: 27559168
Science. 2014 May 9;344(6184):598-602
pubmed: 24812394
Neuron. 2017 Nov 15;96(4):883-896.e7
pubmed: 29056299
Neuron. 2014 Mar 5;81(5):1097-1110
pubmed: 24508384
J Neurosci. 2009 Sep 23;29(38):11852-8
pubmed: 19776271
J Neurosci. 2003 Nov 12;23(32):10411-8
pubmed: 14614100
Trends Neurosci. 2008 Aug;31(8):392-400
pubmed: 18603310
J Neurosci. 2019 Jan 23;39(4):584-595
pubmed: 30674614
Proc Natl Acad Sci U S A. 2010 Aug 31;107(35):15613-8
pubmed: 20679234
Proc Natl Acad Sci U S A. 2018 Mar 6;115(10):2514-2519
pubmed: 29467284
Front Neurosci. 2011 May 02;5:64
pubmed: 21562606
Semin Cell Dev Biol. 2006 Aug;17(4):424-32
pubmed: 16889994
Science. 2003 Jan 3;299(5603):117-20
pubmed: 12511652
Neuron. 2011 May 26;70(4):582-8
pubmed: 21609817
J Neurosci. 2009 Dec 2;29(48):15245-57
pubmed: 19955377
J Neurosci. 2007 Nov 14;27(46):12623-9
pubmed: 18003841
Front Neural Circuits. 2014 Nov 04;8:129
pubmed: 25408637
Elife. 2019 Jul 11;8:
pubmed: 31294694
J Neurosci. 2016 Jan 13;36(2):518-31
pubmed: 26758842
Nat Neurosci. 2010 Jun;13(6):753-8
pubmed: 20453850
J Neurosci. 2008 Mar 12;28(11):2919-32
pubmed: 18337423
J Neurosci Methods. 2009 Sep 15;182(2):189-94
pubmed: 19524609
Sci Rep. 2019 Feb 7;9(1):1649
pubmed: 30733506
Neuron. 2011 May 26;70(4):687-702
pubmed: 21609825
J Comp Neurol. 2011 Aug 1;519(11):2212-24
pubmed: 21456001
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1152-61
pubmed: 23487772
J Neurosci. 2004 Sep 22;24(38):8354-65
pubmed: 15385618
Neuron. 2007 May 24;54(4):559-66
pubmed: 17521569
Nat Neurosci. 2004 Nov;7(11):1233-41
pubmed: 15494728
Elife. 2016 Jun 28;5:
pubmed: 27351103
Annu Rev Neurosci. 2005;28:223-50
pubmed: 16022595
Elife. 2018 Feb 28;7:
pubmed: 29489453
Neuron. 2011 Oct 6;72(1):124-36
pubmed: 21982374
J Comp Neurol. 2007 Apr 20;501(6):825-36
pubmed: 17311323
Elife. 2017 Dec 18;6:
pubmed: 29251592
Cell Rep. 2017 Oct 10;21(2):351-365
pubmed: 29020623
J Neurosci. 2009 Jan 7;29(1):86-97
pubmed: 19129387
Nat Neurosci. 2013 Nov;16(11):1687-91
pubmed: 24056698
J Comp Neurol. 1966 Mar;126(3):337-89
pubmed: 5937257
Nat Commun. 2012;3:1253
pubmed: 23212382
Front Neuroinform. 2016 Feb 16;10:6
pubmed: 26909035
Elife. 2018 Mar 13;7:
pubmed: 29533179
Science. 2016 Dec 2;354(6316):1136-1139
pubmed: 27934762
Neuron. 2016 Apr 6;90(1):101-12
pubmed: 26971949
Science. 2000 Feb 25;287(5457):1433-8
pubmed: 10688783
Nat Protoc. 2014 Nov;9(11):2515-2538
pubmed: 25275789
J Neurosci. 2009 Oct 28;29(43):13532-42
pubmed: 19864566
Front Neuroendocrinol. 2016 Apr;41:99-113
pubmed: 26969795
Cell. 1999 Jun 11;97(6):703-16
pubmed: 10380923
J Neurobiol. 1996 May;30(1):123-76
pubmed: 8727988
EMBO J. 2019 Mar 15;38(6):
pubmed: 30643018
Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17980-5
pubmed: 19815505
Nat Rev Neurosci. 2000 Oct;1(1):67-73
pubmed: 11252770
J Physiol Paris. 2002 Jan-Mar;96(1-2):115-22
pubmed: 11755790
Cell. 2014 Nov 6;159(4):896-910
pubmed: 25417164
Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1823-8
pubmed: 10677540
Neuron. 2020 Aug 5;107(3):566-579.e7
pubmed: 32473095
Trends Neurosci. 2003 Sep;26(9):501-6
pubmed: 12948662
Trends Neurosci. 2011 Jan;34(1):20-30
pubmed: 20980064
Proc Natl Acad Sci U S A. 1982 Jan;79(2):670-4
pubmed: 6952218
Nat Neurosci. 2011 Nov 13;15(1):26-8
pubmed: 22081159
Nat Neurosci. 2012 Jun;15(6):897-904
pubmed: 22581183
J Neurosci. 2008 Mar 5;28(10):2383-93
pubmed: 18322085