The promise of human organoids in the digestive system.

Bile Ducts / cytology Cell Culture Techniques, Three Dimensional / methods Cell Differentiation / physiology Humans Liver / cytology Organogenesis / physiology Organoids / cytology Pancreas / cytology Pluripotent Stem Cells / cytology Tissue Engineering / methods

Journal

Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445

Informations de publication

Date de publication:
01 2021
Historique:
received: 31 03 2020
accepted: 26 10 2020
revised: 23 10 2020
pubmed: 19 11 2020
medline: 21 12 2021
entrez: 18 11 2020
Statut: ppublish

Résumé

The advent of organoid technology has enabled scientists and clinicians to utilize cells from primary tissues or pluripotent stem cells (PSCs) to grow self-organizing tissue systems, thus attaining cellular diversity, spatial organization, and functionality as found within digestive tracts. The development of human gastrointestinal (GI) and hepato-biliary-pancreatic organoids as an in-a-dish model present novel opportunities to study humanistic mechanisms of organogenesis, regeneration and pathogenesis. Herein, we review the recent portfolios of primary tissue-derived and PSC-derived organoids in the digestive systems. We also discuss the promise and challenges in disease modeling and drug development applications for digestive disorders.

Identifiants

DOI: 10.1038/s41418-020-00661-3 PMID: 33204011 PMC: PMC7852589
pubmed: 33204011
doi: 10.1038/s41418-020-00661-3
pii: 10.1038/s41418-020-00661-3
pmc: PMC7852589
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

84-94

Subventions

Organisme : NIDDK NIH HHS
ID : DP2 DK128799
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK078392
Pays : United States
Organisme : NIDDK NIH HHS
ID : UG3 DK119982
Pays : United States
Organisme : NIDDK NIH HHS
ID : UH3 DK119982
Pays : United States

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Auteurs

Masaaki Funata (M)

T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
Takeda-CiRA Joint Program, Fujisawa City, Kanagawa, Japan.

Yasunori Nio (Y)

T-CiRA Discovery, Takeda Pharmaceutical Company Limited, Fujisawa City, Kanagawa, Japan.
Takeda-CiRA Joint Program, Fujisawa City, Kanagawa, Japan.

Derek M Erion (DM)

Gastroenterology Drug Discovery Unit, Takeda Pharmaceutical Company Limited, 35 Landsdowne Street, Cambridge, MA, 02139, USA.

Wendy L Thompson (WL)

Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

Takanori Takebe (T)

Takeda-CiRA Joint Program, Fujisawa City, Kanagawa, Japan. Takanori.Takebe@cchmc.org.
Division of Gastroenterology, Hepatology & Nutrition, Developmental Biology, Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. Takanori.Takebe@cchmc.org.
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Takanori.Takebe@cchmc.org.
Institute of Research, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Takanori.Takebe@cchmc.org.
Communication Design Center, Advanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa, Japan. Takanori.Takebe@cchmc.org.
ORCID: 0000-0002-6989-3041

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Classifications MeSH

questionsmedicales.fr › Système digestif › Voies biliaires › Conduits biliaires › The promise of human organoids in the digestive system.
questionsmedicales.fr › Techniques d'investigation › Techniques in vitro › Techniques de culture › Techniques de culture cellulaire › Techniques de cultures cellulaires tridimensionnelles › The promise of human organoids in the digestive system.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › The promise of human organoids in the digestive system.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The promise of human organoids in the digestive system.
questionsmedicales.fr › Système digestif › Foie › The promise of human organoids in the digestive system.
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Organogenèse › The promise of human organoids in the digestive system.
questionsmedicales.fr › Tissus › Organoïdes › The promise of human organoids in the digestive system.
questionsmedicales.fr › Système digestif › Pancréas › The promise of human organoids in the digestive system.
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches pluripotentes › The promise of human organoids in the digestive system.
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › The promise of human organoids in the digestive system.