Fit older adults with advanced myelodysplastic syndromes: who is most likely to benefit from transplant?


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
04 2021
Historique:
received: 07 07 2020
accepted: 31 10 2020
pubmed: 19 11 2020
medline: 1 5 2021
entrez: 18 11 2020
Statut: ppublish

Résumé

We conducted a prospective observational study of fit adults aged 60-75 with advanced MDS, enrolled hierarchically for adverse MDS risk (intermediate-2 or high-risk international prognostic score [IPSS], low or intermediate-1 IPSS with poor-risk cytogenetics, or therapy-related MDS) or standard risk with severe cytopenia. A total of 290 patients enrolled at two centers: 175 for adverse risk and 115 for standard risk with severe cytopenia. 113 underwent HCT after a median of 5 months; median follow-up for all was 39.5 months. In univariable analyses, the hazard ratio (HR) for death comparing HCT with no HCT was 0.84 (p = 0.30). The HR for death was 0.64 (p = 0.04) for HCT ≤ 5 months after enrollment and 1.20 (p = 0.39) for HCT > 5 months. In multivariable analyses controlling for age, gender, ECOG performance status, cytogenetic risk, and IPSS risk group, HR for death was 0.75 (p = 0.13) for HCT compared to no HCT, 0.57 (p = 0.01) for adverse MDS risk and 1.33 (p = 0.36) for standard risk with severe cytopenia. In this large, prospective cohort of fit older adults with advanced MDS, we found that survival was significantly improved if HCT was performed early or for adverse risk disease but not for standard risk disease with severe cytopenia.

Identifiants

pubmed: 33204012
doi: 10.1038/s41375-020-01092-2
pii: 10.1038/s41375-020-01092-2
pmc: PMC8035144
mid: NIHMS1642988
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1166-1175

Subventions

Organisme : NCI NIH HHS
ID : P01 CA229092
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA206963
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA092203
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA092203
Pays : United States

Commentaires et corrections

Type : ErratumIn

Références

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Auteurs

Gregory A Abel (GA)

Dana-Farber Cancer Institute, Boston, MA, USA. gregory_abel@dfci.harvard.edu.

Haesook T Kim (HT)

Dana-Farber Cancer Institute, Boston, MA, USA.
Harvard School of Public Health, Boston, MA, USA.

Andrew Hantel (A)

Dana-Farber Cancer Institute, Boston, MA, USA.

David P Steensma (DP)

Dana-Farber Cancer Institute, Boston, MA, USA.

Richard Stone (R)

Dana-Farber Cancer Institute, Boston, MA, USA.

Anand Habib (A)

Dana-Farber Cancer Institute, Boston, MA, USA.

Vincent T Ho (VT)

Dana-Farber Cancer Institute, Boston, MA, USA.

Martha Wadleigh (M)

Dana-Farber Cancer Institute, Boston, MA, USA.

Areej El-Jawahri (A)

Massachusetts General Hospital, Boston, MA, USA.

Edwin P Alyea (EP)

Duke Cancer Institute, Durham, NC, USA.

Daniel J DeAngelo (DJ)

Dana-Farber Cancer Institute, Boston, MA, USA.

John Koreth (J)

Dana-Farber Cancer Institute, Boston, MA, USA.

Joseph H Antin (JH)

Dana-Farber Cancer Institute, Boston, MA, USA.

Robert J Soiffer (RJ)

Dana-Farber Cancer Institute, Boston, MA, USA.

Corey Cutler (C)

Dana-Farber Cancer Institute, Boston, MA, USA.

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