Fit older adults with advanced myelodysplastic syndromes: who is most likely to benefit from transplant?
Age Factors
Aged
Biomarkers
Clinical Decision-Making
Disease Management
Female
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Male
Middle Aged
Mutation
Myelodysplastic Syndromes
/ diagnosis
Neoplasm Grading
Neoplasm Staging
Patient Selection
Prognosis
Severity of Illness Index
Transplantation, Homologous
Treatment Outcome
Journal
Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
07
07
2020
accepted:
31
10
2020
pubmed:
19
11
2020
medline:
1
5
2021
entrez:
18
11
2020
Statut:
ppublish
Résumé
We conducted a prospective observational study of fit adults aged 60-75 with advanced MDS, enrolled hierarchically for adverse MDS risk (intermediate-2 or high-risk international prognostic score [IPSS], low or intermediate-1 IPSS with poor-risk cytogenetics, or therapy-related MDS) or standard risk with severe cytopenia. A total of 290 patients enrolled at two centers: 175 for adverse risk and 115 for standard risk with severe cytopenia. 113 underwent HCT after a median of 5 months; median follow-up for all was 39.5 months. In univariable analyses, the hazard ratio (HR) for death comparing HCT with no HCT was 0.84 (p = 0.30). The HR for death was 0.64 (p = 0.04) for HCT ≤ 5 months after enrollment and 1.20 (p = 0.39) for HCT > 5 months. In multivariable analyses controlling for age, gender, ECOG performance status, cytogenetic risk, and IPSS risk group, HR for death was 0.75 (p = 0.13) for HCT compared to no HCT, 0.57 (p = 0.01) for adverse MDS risk and 1.33 (p = 0.36) for standard risk with severe cytopenia. In this large, prospective cohort of fit older adults with advanced MDS, we found that survival was significantly improved if HCT was performed early or for adverse risk disease but not for standard risk disease with severe cytopenia.
Identifiants
pubmed: 33204012
doi: 10.1038/s41375-020-01092-2
pii: 10.1038/s41375-020-01092-2
pmc: PMC8035144
mid: NIHMS1642988
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1166-1175Subventions
Organisme : NCI NIH HHS
ID : P01 CA229092
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA206963
Pays : United States
Organisme : NCI NIH HHS
ID : R25 CA092203
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA092203
Pays : United States
Commentaires et corrections
Type : ErratumIn
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