Allergy and immunology in young children of Japan: The JECS cohort.
Asthma
Atopic dermatitis
Atopic dermatitis, AD
Atopic march
Children
Eczema
Epidemiology
Food allergy
GI, gastrointestinal
ISAAC, The International Study of Asthma and Allergies in Childhood
Kawasaki disease
Kawasaki disease, KD
Primary immune deficiency
University Hospital Medical Information Network, UMIN
Wheeze
food protein-induced enterocolitis syndrome, FPIES
primary immunodeficiency disorder, PID
Journal
The World Allergy Organization journal
ISSN: 1939-4551
Titre abrégé: World Allergy Organ J
Pays: United States
ID NLM: 101481283
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
17
07
2020
revised:
30
09
2020
accepted:
12
10
2020
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
19
11
2020
Statut:
epublish
Résumé
Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented. To characterize epidemiological signatures of allergic and immunological disease in young children in Japan. This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data. The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years. These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency.
Sections du résumé
BACKGROUND
BACKGROUND
Capturing epidemiological signatures is essential to document burdens of disease and to design health care services, including prevention measures, clinical interventions, and policies. There are large geographical and ethnic variations in the epidemiology of allergic and immunological diseases. Various data are available from North America and Europe, but the epidemiology of allergic and immunological diseases in Asia is not well documented.
OBJECTIVE
OBJECTIVE
To characterize epidemiological signatures of allergic and immunological disease in young children in Japan.
METHODS
METHODS
This was a national, multicenter, prospective birth cohort study: Japan Environment and Children's Study (JECS). A general population of 103,060 women was enrolled during pregnancy. Allergic and immunological outcomes were assessed among young children using questionnaire data.
RESULTS
RESULTS
The prevalence of caregiver-reported immediate food allergy was 7.6%, 6.7%, and 4.9% at age 1, 2, and 3 years, respectively. Hen egg allergy was most common (5.4% prevalence at age 1 year) followed by allergies to cow milk and wheat. Several patterns of allergic symptom clusters were identified. Physician diagnosed, as reported by the caregiver, non-IgE mediated gastrointestinal food allergy affected 0.5% of infants. By contrast, caregiver-reported gastrointestinal food allergies affected 1.4% of children. Kawasaki disease affected 0.3% and 0.4% children, respectively, at age 1 and 3 years. Primary immunodeficiency disorders affected 0.005% children at age 3 years.
CONCLUSION
CONCLUSIONS
These data provide important epidemiological signatures of allergy and immunology in young Japanese children including the age-specific prevalence of allergic disease, Kawasaki disease, and primary immune deficiency.
Identifiants
pubmed: 33204389
doi: 10.1016/j.waojou.2020.100479
pii: S1939-4551(20)30382-3
pmc: PMC7652713
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100479Investigateurs
Michihiro Kamijima
(M)
Shin Yamazaki
(S)
Yukihiro Ohya
(Y)
Reiko Kishi
(R)
Nobuo Yaegashi
(N)
Koichi Hashimoto
(K)
Chisato Mori
(C)
Shuichi Ito
(S)
Zentaro Yamagata
(Z)
Hidekuni Inadera
(H)
Takeo Nakayama
(T)
Hiroyasu Iso
(H)
Masayuki Shima
(M)
Youichi Kurozawa
(Y)
Narufumi Suganuma
(N)
Koichi Kusuhara
(K)
Takahiko Katoh
(T)
Informations de copyright
© 2020 The Author(s).
Déclaration de conflit d'intérêts
The authors declare that they have no competing interests related to the contents of this study.
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