Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long-term evaluation.
aggressive periodontitis
gingival crevicular fluid
inflammation
long-term effects
therapy
Journal
Journal of clinical periodontology
ISSN: 1600-051X
Titre abrégé: J Clin Periodontol
Pays: United States
ID NLM: 0425123
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
18
06
2020
revised:
27
10
2020
accepted:
09
11
2020
pubmed:
19
11
2020
medline:
22
4
2021
entrez:
18
11
2020
Statut:
ppublish
Résumé
To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance. Sixty-six African-Americans with LAP (7-21 years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin/metronidazole for 7 days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24 months following treatment. Levels of 16 inflammatory/bone resorption markers were determined using Milliplex Reductions in the clinical parameters (except for visible plaque) were observed at all time points compared to the baseline. Levels of IL-12p70, IL-2, IL-6, MIP-1α, RANKL, and OPG were reduced after treatment, and several cytokines/chemokines were correlated with clinical parameters reductions. DA showed that differences in the immunoinflammatory profiles between LAP diseased and healthy sites decreased after periodontal treatment compared to the baseline. Periodontal treatment modified the local immunoinflammatory profile of LAP sites in the long term, as suggested by changes in biomarkers from baseline, along with clinical stability of the disease. (Clinicaltrials.gov number, NCT01330719).
Identifiants
pubmed: 33205510
doi: 10.1111/jcpe.13404
pmc: PMC7825363
mid: NIHMS1647796
doi:
Substances chimiques
Chemokines
0
Cytokines
0
Amoxicillin
804826J2HU
Banques de données
ClinicalTrials.gov
['NCT01330719']
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
237-248Subventions
Organisme : NIDCR NIH HHS
ID : R01 DE019456
Pays : United States
Organisme : NIDCR NIH HHS
ID : R90 DE022530
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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