Cell senescence: basic mechanisms and the need for computational networks in vascular ageing.
Algorithms
Animals
Blood Vessels
/ metabolism
Cell Cycle Checkpoints
Cell Cycle Proteins
/ genetics
Cell Proliferation
Cellular Senescence
Computational Biology
Gene Expression Regulation
Gene Regulatory Networks
Humans
Protein Interaction Maps
Proteomics
Signal Transduction
Systems Biology
Vascular Diseases
/ genetics
Epigenetics
Protein network
Senescence
Senolytic drugs
Vascular ageing
Journal
Cardiovascular research
ISSN: 1755-3245
Titre abrégé: Cardiovasc Res
Pays: England
ID NLM: 0077427
Informations de publication
Date de publication:
07 07 2021
07 07 2021
Historique:
received:
01
06
2020
revised:
26
08
2020
accepted:
28
10
2020
pubmed:
19
11
2020
medline:
8
2
2022
entrez:
18
11
2020
Statut:
ppublish
Résumé
This review seeks to provide an update of the mechanisms of vascular cell senescence, from newly identified molecules to arterial ageing phenotypes, and finally to present a computational approach to connect these selected proteins in biological networks. We will discuss current key signalling and gene expression pathways by which these focus proteins and networks drive normal and accelerated vascular ageing. We also review the possibility that senolytic drugs, designed to restore normal cell differentiation and function, could effectively treat multiple age-related vascular diseases. Finally, we discuss how cell senescence is both a cause and a consequence of vascular ageing because of the possible feedback controls between identified networks.
Identifiants
pubmed: 33206947
pii: 5952674
doi: 10.1093/cvr/cvaa318
doi:
Substances chimiques
Cell Cycle Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1841-1858Subventions
Organisme : Region Grand-Est
Organisme : Fonds Européen de Développement Regional
Organisme : Federation Française de Cardiologie
Informations de copyright
Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2020. For permissions, please email: journals.permissions@oup.com.