The IMEx coronavirus interactome: an evolving map of Coronaviridae-host molecular interactions.
Journal
Database : the journal of biological databases and curation
ISSN: 1758-0463
Titre abrégé: Database (Oxford)
Pays: England
ID NLM: 101517697
Informations de publication
Date de publication:
01 01 2020
01 01 2020
Historique:
received:
16
06
2020
revised:
19
10
2020
accepted:
23
10
2020
entrez:
18
11
2020
pubmed:
19
11
2020
medline:
1
12
2020
Statut:
ppublish
Résumé
The current coronavirus disease of 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2, has spurred a wave of research of nearly unprecedented scale. Among the different strategies that are being used to understand the disease and develop effective treatments, the study of physical molecular interactions can provide fine-grained resolution of the mechanisms behind the virus biology and the human organism response. We present a curated dataset of physical molecular interactions focused on proteins from SARS-CoV-2, SARS-CoV-1 and other members of the Coronaviridae family that has been manually extracted by International Molecular Exchange (IMEx) Consortium curators. Currently, the dataset comprises over 4400 binarized interactions extracted from 151 publications. The dataset can be accessed in the standard formats recommended by the Proteomics Standards Initiative (HUPO-PSI) at the IntAct database website (https://www.ebi.ac.uk/intact) and will be continuously updated as research on COVID-19 progresses.
Identifiants
pubmed: 33206959
pii: 5989498
doi: 10.1093/database/baaa096
pmc: PMC7673336
pii:
doi:
Substances chimiques
Viral Proteins
0
Types de publication
Dataset
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM123126
Pays : United States
Organisme : NHGRI NIH HHS
ID : U24 HG007822
Pays : United States
Commentaires et corrections
Type : UpdateOf
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press.
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