A new sesquineolignan and four new neolignans isolated from the leaves of Piper betle, a traditional medicinal plant in Myanmar.

Animals Anti-Inflammatory Agents, Non-Steroidal / chemistry Dose-Response Relationship, Drug Lignans / chemistry Lipopolysaccharides / antagonists & inhibitors Medicine, Traditional Mice Molecular Structure Myanmar Nitric Oxide / antagonists & inhibitors Piper betle / chemistry Plant Leaves / chemistry Plants, Medicinal / chemistry RAW 264.7 Cells Structure-Activity Relationship
Anti-inflammatory Myanmar Neolignans Piper betle Piperaceae

Journal

Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377

Informations de publication

Date de publication:
01 01 2021
Historique:
received: 25 06 2020
revised: 04 10 2020
accepted: 06 11 2020
pubmed: 19 11 2020
medline: 23 7 2021
entrez: 18 11 2020
Statut: ppublish

Résumé

One new sesquineolignan, piperneolignan A (1), four new neolignans, piperneolignans B-E (2-5), and eight known compounds were isolated from the leaves of Piper betle (Piperaceae) collected from Myanmar. These new structures were determined by analysis of MS and NMR data, and the absolute configuration of piperneolignan A was elucidated by electronic circular dichroism (ECD) calculations. Piperneolignan A (1), piperneolignan B (2), hydroxychavicol (6), p-hydroxycinnamaldehyde (10), and diallylcatechol (13) possessed anti-inflammatory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cells with IC

Identifiants

DOI: 10.1016/j.bmcl.2020.127682 PMID: 33207281
pubmed: 33207281
pii: S0960-894X(20)30793-9
doi: 10.1016/j.bmcl.2020.127682
pii:
doi:

Substances chimiques

Anti-Inflammatory Agents, Non-Steroidal 0
Lignans 0
Lipopolysaccharides 0
Nitric Oxide 31C4KY9ESH

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

127682

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Thae Thae San (TT)

Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar; Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.

Yue-Hu Wang (YH)

Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar; Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

Dong-Bao Hu (DB)

School of Chemical Biology and Environment, Yuxi Normal University, Yuxi 653100, People's Republic of China.

Jun Yang (J)

Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar; Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

Dong-Dong Zhang (DD)

Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar; Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

Meng-Yuan Xia (MY)

Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.

Xue-Fei Yang (XF)

Southeast Asia Biodiversity Research Institute, Chinese Academy of Sciences, Yezin, Nay Pyi Taw 05282, Myanmar; Key Laboratory of Economic Plants and Biotechnology and the Yunnan Key Laboratory for Wild Plant Resources, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: xuefei@mail.kib.ac.cn.

Yong-Ping Yang (YP)

Key Laboratory for Plant Diversity and Biogeography of East Asia, Institute of Tibetan Plateau Research at Kunming, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China. Electronic address: yangyp@mail.kib.ac.cn.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antirhumatismaux › Anti-inflammatoires non stéroïdiens › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Composés benzyliques › Lignanes › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Sciences sociales › Anthropologie › Anthropologie culturelle › Médecine traditionnelle › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Régions géographiques › Asie › Asie du Sud-Est › Myanmar › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Monoxyde d'azote › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Piperaceae › Piper › Piper betle › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Structures de plante › Parties aériennes de plante › Feuilles de plante › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Eucaryotes › Plantes › Plantes médicinales › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Cellules › Cellules RAW 264.7 › A new sesquineolignan and four new neolignans...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › A new sesquineolignan and four new neolignans...