BNIP3 in Lung Cancer: To Kill or Rescue?
BNIP3
apoptosis
autophagy
lung cancer
metastasis
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
16 Nov 2020
16 Nov 2020
Historique:
received:
09
10
2020
revised:
06
11
2020
accepted:
13
11
2020
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Bcl-2/adenovirus E1B 19kDa interacting protein 3 (BNIP3) is a pro-apoptotic BH3-only protein of the Bcl-2 family. Initially, BNIP3 was described as one of the mediators of hypoxia-induced apoptotic cell death in cardiac myocytes and neurons. Besides apoptosis, BNIP3 plays a crucial role in autophagy, metabolic pathways, and metastasis-related processes in different tumor types. Lung cancer is one of the most aggressive types of cancer, which is often diagnosed at an advanced stage. Therefore, there is still urgent demand for reliable biochemical markers for lung cancer and its efficient treatment. Mitochondria functioning and mitochondrial proteins, including BNIP3, have a strong impact on lung cancer development and progression. Here, we summarized current knowledge about the BNIP3 gene and protein features and their role in cancer progression, especially in lung cancer in order to develop new therapeutic approaches associated with BNIP3.
Identifiants
pubmed: 33207677
pii: cancers12113390
doi: 10.3390/cancers12113390
pmc: PMC7697772
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Russian Science Foundation
ID : 19-15-00125
Organisme : Russian Foundation for Basic Research
ID : 20-315-90019
Organisme : Russian Foundation for Basic Research
ID : 19-015-00332
Organisme : Cancerfonden
ID : 190345
Organisme : Radiumhemmets Forskningsfonder
ID : 181301
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