Network-based atrophy modeling in the common epilepsies: A worldwide ENIGMA study.

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
11 2020
Historique:
received: 06 05 2020
accepted: 05 10 2020
entrez: 19 11 2020
pubmed: 20 11 2020
medline: 20 11 2020
Statut: epublish

Résumé

Epilepsy is increasingly conceptualized as a network disorder. In this cross-sectional mega-analysis, we integrated neuroimaging and connectome analysis to identify network associations with atrophy patterns in 1021 adults with epilepsy compared to 1564 healthy controls from 19 international sites. In temporal lobe epilepsy, areas of atrophy colocalized with highly interconnected cortical hub regions, whereas idiopathic generalized epilepsy showed preferential subcortical hub involvement. These morphological abnormalities were anchored to the connectivity profiles of distinct disease epicenters, pointing to temporo-limbic cortices in temporal lobe epilepsy and fronto-central cortices in idiopathic generalized epilepsy. Negative effects of age on atrophy further revealed a strong influence of connectome architecture in temporal lobe, but not idiopathic generalized, epilepsy. Our findings were reproduced across individual sites and single patients and were robust across different analytical methods. Through worldwide collaboration in ENIGMA-Epilepsy, we provided deeper insights into the macroscale features that shape the pathophysiology of common epilepsies.

Identifiants

DOI: 10.1126/sciadv.abc6457 PMID: 33208365 PMC: PMC7673818
pubmed: 33208365
pii: 6/47/eabc6457
doi: 10.1126/sciadv.abc6457
pmc: PMC7673818
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIBIB NIH HHS
ID : P41 EB015922
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS107739
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116147
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : Medical Research Council
ID : MR/K023152/1
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : R01 NS110347
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS122827
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS065838
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : NIA NIH HHS
ID : R56 AG058854
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Sara Larivière (S)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.
ORCID: 0000-0001-5701-1307

Raúl Rodríguez-Cruces (R)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Jessica Royer (J)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Maria Eugenia Caligiuri (ME)

Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.

Antonio Gambardella (A)

Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy.

Luis Concha (L)

Institute of Neurobiology, Universidad Nacional Autónoma de México, Querétaro, México.

Simon S Keller (SS)

Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.
Walton Centre NHS Foundation Trust, Liverpool, UK.

Fernando Cendes (F)

Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.

Clarissa Yasuda (C)

Department of Neurology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil.
ORCID: 0000-0001-9084-7173

Leonardo Bonilha (L)

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Ezequiel Gleichgerrcht (E)

Department of Neurology, Medical University of South Carolina, Charleston, SC, USA.

Niels K Focke (NK)

Department of Clinical Neurophysiology, University of Medicine Göttingen, Göttingen, Germany.

Martin Domin (M)

Institute of Diagnostic Radiology and Neuroradiology, Functional Imaging Unit, University Medicine Greifswald, Greifswald, Germany.

Felix von Podewills (F)

Department of Neurology, University Medicine Greifswald, Greifswald, Germany.

Soenke Langner (S)

Institute of Diagnostic Radiology and Neuroradiology, University Medicine Greifswald, Greifswald, Germany.

Christian Rummel (C)

Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.

Roland Wiest (R)

Support Center for Advanced Neuroimaging (SCAN), University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Bern, Switzerland.

Pascal Martin (P)

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Raviteja Kotikalapudi (R)

Department of Neurology and Epileptology, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany.

Terence J O'Brien (TJ)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Benjamin Sinclair (B)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Lucy Vivash (L)

Department of Neuroscience, Central Clinical School, Alfred Hospital, Monash University, Melbourne, Victoria, Australia.
Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Patricia M Desmond (PM)

Departments of Medicine and Radiology, The Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia.

Saud Alhusaini (S)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Colin P Doherty (CP)

Department of Neurology, St. James' Hospital, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.

Gianpiero L Cavalleri (GL)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.
ORCID: 0000-0002-9802-0506

Norman Delanty (N)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.
FutureNeuro SFI Research Centre, Dublin, Ireland.

Reetta Kälviäinen (R)

Epilepsy Center, Neuro Center, Kuopio University Hospital, European Reference Network for Rare and Complex Epilepsies EpiCARE, Kuopio, Finland.
Faculty of Health Sciences, School of Medicine, Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.

Graeme D Jackson (GD)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.

Magdalena Kowalczyk (M)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.

Mario Mascalchi (M)

Neuroradiology Research Program, Meyer Children Hospital of Florence, University of Florence, Florence, Italy.

Mira Semmelroch (M)

Florey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria 3010, Australia.

Rhys H Thomas (RH)

Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

Hamid Soltanian-Zadeh (H)

Control and Intelligent Processing Center of Excellence (CIPCE), School of Electrical and Computer Engineering, University of Tehran, Tehran, Iran.
Departments of Research Administration and Radiology, Henry Ford Health System, Detroit, MI, USA.

Esmaeil Davoodi-Bojd (E)

Department of Neurology, Henry Ford Health System, Detroit, MI, USA.

Junsong Zhang (J)

Cognitive Science Department, Xiamen University, Xiamen, China.

Matteo Lenge (M)

Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy.
Functional and Epilepsy Neurosurgery Unit, Neurosurgery Department, Children's Hospital A. Meyer-University of Florence, Italy.

Renzo Guerrini (R)

Child Neurology Unit and Laboratories, Neuroscience Department, Children's Hospital A. Meyer-University of Florence, Italy.

Emanuele Bartolini (E)

USL Centro Toscana, Neurology Unit, Nuovo Ospedale Santo Stefano, Prato, Italy.

Khalid Hamandi (K)

Cardiff University Brain Research Imaging Centre (CUBRIC), College of Biomedical Sciences, Cardiff University, Cardiff, UK.
Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.

Sonya Foley (S)

Welsh Epilepsy Unit, Department of Neurology, University Hospital of Wales, Cardiff, UK.

Bernd Weber (B)

Institute of Experimental Epileptology and Cognition Research, University Hospital Bonn, Bonn, Germany.

Chantal Depondt (C)

Department of Neurology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.
ORCID: 0000-0002-8452-5319

Julie Absil (J)

Department of Radiology, Hôpital Erasme, Université Libre de Bruxelles, Brussels, Belgium.

Sarah J A Carr (SJA)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Eugenio Abela (E)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Mark P Richardson (MP)

Division of Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Orrin Devinsky (O)

Department of Neurology, NYU Grossman School of Medicine, New York, NY, USA.

Mariasavina Severino (M)

IRCCS Istituto Giannina Gaslini, Genova, Italy.

Pasquale Striano (P)

IRCCS Istituto Giannina Gaslini, Genova, Italy.

Domenico Tortora (D)

IRCCS Istituto Giannina Gaslini, Genova, Italy.

Sean N Hatton (SN)

Department of Neurosciences, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.

Sjoerd B Vos (SB)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.
Centre for Medical Image Computing, University College London, London, UK.

John S Duncan (JS)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.

Christopher D Whelan (CD)

Department of Molecular and Cellular Therapeutics, The Royal College of Surgeons in Ireland, Dublin, Ireland.

Paul M Thompson (PM)

Imaging Genetics Center, Mark and Mary Stevens Institute for Neuroimaging and Informatics, USC Keck School of Medicine, Los Angeles, CA, USA.
ORCID: 0000-0002-4720-8867

Sanjay M Sisodiya (SM)

Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, London, UK.
Chalfont Centre for Epilepsy, Bucks, UK.

Andrea Bernasconi (A)

Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Angelo Labate (A)

Neuroscience Research Center, University Magna Græcia, Catanzaro, CZ, Italy.
Institute of Neurology, University Magna Græcia, Catanzaro, CZ, Italy.

Carrie R McDonald (CR)

Department of Psychiatry, Center for Multimodal Imaging and Genetics, University of California San Diego, La Jolla, CA, USA.

Neda Bernasconi (N)

Neuroimaging of Epilepsy Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada.

Boris C Bernhardt (BC)

Multimodal Imaging and Connectome Analysis Laboratory, McConnell Brain Imaging Centre, Montreal Neurological Institute and Hospital, McGill University, Montreal, QC, Canada. boris.bernhardt@mcgill.ca.
ORCID: 0000-0001-9256-6041

Classifications MeSH