Systematic Examination of Antigen-Specific Recall T Cell Responses to SARS-CoV-2 versus Influenza Virus Reveals a Distinct Inflammatory Profile.
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 01 2021
01 01 2021
Historique:
received:
16
09
2020
accepted:
02
11
2020
pubmed:
20
11
2020
medline:
23
1
2021
entrez:
19
11
2020
Statut:
ppublish
Résumé
There is a pressing need for an in-depth understanding of immunity to SARS-CoV-2. In this study, we investigated human T cell recall responses to fully glycosylated spike trimer, recombinant N protein, as well as to S, N, M, and E peptide pools in the early convalescent phase and compared them with influenza-specific memory responses from the same donors. All subjects showed SARS-CoV-2-specific T cell responses to at least one Ag. Both SARS-CoV-2-specific and influenza-specific CD4
Identifiants
pubmed: 33208459
pii: jimmunol.2001067
doi: 10.4049/jimmunol.2001067
pmc: PMC7750861
doi:
Substances chimiques
Antigens, Viral
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
37-50Informations de copyright
Copyright © 2020 by The American Association of Immunologists, Inc.
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