Increased IL-10-producing regulatory T cells are characteristic of severe cases of COVID-19.
COVID‐19
IL‐10
SARS‐CoV‐2
T regulatory cells
open resource
systems immunology
Journal
Clinical & translational immunology
ISSN: 2050-0068
Titre abrégé: Clin Transl Immunology
Pays: Australia
ID NLM: 101638268
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
08
2020
revised:
08
10
2020
accepted:
09
10
2020
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
The pandemic spread of the coronavirus SARS-CoV-2 is due, in part, to the immunological properties of the host-virus interaction. The clinical presentation varies from individual to individual, with asymptomatic carriers, mild-to-moderate-presenting patients and severely affected patients. Variation in immune response to SARS-CoV-2 may underlie this clinical variation. Using a high-dimensional systems immunology platform, we have analysed the peripheral blood compartment of 6 healthy individuals, 23 mild-to-moderate and 20 severe COVID-19 patients. We identify distinct immunological signatures in the peripheral blood of the mild-to-moderate and severe COVID-19 patients, including T-cell lymphopenia, more consistent with peripheral hypo- than hyper-immune activation. Unique to the severe COVID-19 cases was a large increase in the proportion of IL-10-secreting regulatory T cells, a lineage known to possess anti-inflammatory properties in the lung. As IL-10-secreting regulatory T cells are known to possess anti-inflammatory properties in the lung, their proportional increase could contribute to a more severe COVID-19 phenotype. We openly provide annotated data (https://flowrepository.org/experiments/2713) with clinical correlates as a systems immunology resource for the COVID-19 research community.
Identifiants
pubmed: 33209300
doi: 10.1002/cti2.1204
pii: CTI21204
pmc: PMC7662088
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e1204Investigateurs
Francesca Bosisio
(F)
Frederik De Smet
(F)
Christophe Dooms
(C)
Abhishek Garg
(A)
Jan Gunst
(J)
Greet Hermans
(G)
Diether Lambrechts
(D)
Natalie Lorent
(N)
Kim Martinod
(K)
Patrick Matthys
(P)
Philippe Meersseman
(P)
Johan Neyts
(J)
Paul Proost
(P)
Jeroen Raes
(J)
Sabine Tejpar
(S)
Dries Testelmans
(D)
Karin Thevissen
(K)
Robin Vos
(R)
Birgit Weynand
(B)
Alexander Wilmer
(A)
Carine Wouters
(C)
Jonas Yserbyt
(J)
Informations de copyright
© 2020 The Authors. Clinical & Translational Immunology published by John Wiley & Sons Australia, Ltd on behalf of Australian and New Zealand Society for Immunology, Inc.
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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