Indications for early plasma transfusion and its optimal use following trauma.
Blood component transfusion
Injury Severity Score
Trauma Severity Index
hemostasis
plasma volume
Journal
Acute medicine & surgery
ISSN: 2052-8817
Titre abrégé: Acute Med Surg
Pays: United States
ID NLM: 101635464
Informations de publication
Date de publication:
Historique:
received:
23
06
2020
revised:
07
10
2020
accepted:
11
10
2020
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
This study aimed to evaluate the effect of plasma transfusion before urgent hemostasis initiation on in-hospital mortality in hemodynamically unstable patients with severe trauma. This retrospective observational study of patients admitted to hospital between January 2011 and January 2019 grouped patients according to whether plasma transfusion was initiated before (Before group) or after (After group) hemostasis initiation. Patients with severe trauma who were unable to wait for plasma transfusion and had started hemostasis before the plasma infusion were excluded. We used multivariable logistic regression analysis to determine the effect of plasma transfusion before the initiation of urgent hemostasis on in-hospital mortality. We included 47 and 73 patients in the Before and After groups, respectively. Blunt trauma was more common, and the D-dimer levels and Injury Severity Score were significantly higher in the Before group than in the After group (median D-dimer, 57.5 versus 38.1 μg/mL; Plasma transfusion before hemostasis initiation could be an important factor for improving outcomes in hemodynamically unstable patients with blunt trauma, high D-dimer levels, or a high Injury Severity Score.
Identifiants
pubmed: 33209332
doi: 10.1002/ams2.593
pii: AMS2593
pmc: PMC7659524
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e593Informations de copyright
© 2020 The Authors. Acute Medicine & Surgery published by John Wiley & Sons Australia, Ltd on behalf of Japanese Association for Acute Medicine.
Déclaration de conflit d'intérêts
Approval of the research protocol: The research protocol was approved by the Tokai University Institutional Review Board for Clinical Research (Approval number: 18R‐326), and conformed to the provisions of the Declaration of Helsinki (as revised in Fortaleza, Brazil, October 2013). All methods were carried out in accordance with relevant guidelines and regulations. Informed consent: The institutional review board waived the need for patient consent. Registry and the registration no. of the study/trial: N/A. Animal studies: N/A. Conflict of interest: None.
Références
Crit Care Med. 2012 Apr;40(4):1129-35
pubmed: 22020243
J Trauma. 2006 Jun;60(6 Suppl):S3-11
pubmed: 16763478
N Engl J Med. 2018 Jul 26;379(4):315-326
pubmed: 30044935
JAMA. 2015 Feb 3;313(5):471-82
pubmed: 25647203
JAMA Surg. 2013 Feb;148(2):127-36
pubmed: 23560283
J Trauma Acute Care Surg. 2015 Dec;79(6):897-903; discussion 903-4
pubmed: 26680132
J Am Coll Surg. 2010 Jun;210(6):957-65
pubmed: 20510805
Br J Surg. 2018 Oct;105(11):1426-1434
pubmed: 29999518
Ann Surg. 2019 Apr 13;:
pubmed: 30998533
J Trauma. 2009 Aug;67(2):221-7; discussion 228-30
pubmed: 19667872
J Trauma Acute Care Surg. 2014 Mar;76(3):582-92, discussion 592-3
pubmed: 24553523
J Trauma Acute Care Surg. 2019 Jan;86(1):108-115
pubmed: 30358770
Lancet. 2018 Jul 28;392(10144):283-291
pubmed: 30032977
Shock. 2016 May;45(5):495-501
pubmed: 26863127
Ann Surg. 2008 Oct;248(4):578-84
pubmed: 18936570
Blood Adv. 2018 Jul 24;2(14):1696-1704
pubmed: 30030268
Lancet. 2012 Sep 22;380(9847):1099-108
pubmed: 22998719
J Trauma Acute Care Surg. 2016 Apr;80(4):576-84; discussion 584-5
pubmed: 26808040
J Trauma Acute Care Surg. 2014 Dec;77(6):811-7; discussion 817
pubmed: 25051384
J Trauma. 2002 Mar;52(3):420-5
pubmed: 11901314
JAMA Surg. 2017 Jun 1;152(6):574-580
pubmed: 28273299
JAMA Surg. 2013 Feb;148(2):170-5
pubmed: 23426594
Acute Med Surg. 2018 Jul 15;5(4):342-349
pubmed: 30338080