Clinicoradiopathological features and prognosis according to genomic alterations in patients with resected lung adenocarcinoma.

Kirsten rat sarcoma viral oncogene homolog (KRAS) Lung adenocarcinoma anaplastic lymphoma kinase (ALK) epidermal growth factor receptor (EGFR) solidity

Journal

Journal of thoracic disease
ISSN: 2072-1439
Titre abrégé: J Thorac Dis
Pays: China
ID NLM: 101533916

Informations de publication

Date de publication:
Oct 2020
Historique:
entrez: 19 11 2020
pubmed: 20 11 2020
medline: 20 11 2020
Statut: ppublish

Résumé

We investigated the clinicoradiopathological features and prognosis according to genomic alterations in patients with surgically resected lung adenocarcinoma. Patients who underwent surgical resection for pathologic stage I, II, or IIIA lung adenocarcinoma between 2009 and 2016 and for whom results regarding Of 164 patients, 86 (52.4%) were female and 94 (57.3%) were never-smokers. The most common imaging patterns were part-solid lesion (67.7%) followed by solid (26.2%) and non-solid (6.1%) lesions. Genomic alterations are associated with clinicoradiopathologic features in patients with resected lung adenocarcinoma. Identifying genomic alterations could help to predict the prognosis of early-stage lung adenocarcinoma.

Sections du résumé

BACKGROUND BACKGROUND
We investigated the clinicoradiopathological features and prognosis according to genomic alterations in patients with surgically resected lung adenocarcinoma.
METHODS METHODS
Patients who underwent surgical resection for pathologic stage I, II, or IIIA lung adenocarcinoma between 2009 and 2016 and for whom results regarding
RESULTS RESULTS
Of 164 patients, 86 (52.4%) were female and 94 (57.3%) were never-smokers. The most common imaging patterns were part-solid lesion (67.7%) followed by solid (26.2%) and non-solid (6.1%) lesions.
CONCLUSIONS CONCLUSIONS
Genomic alterations are associated with clinicoradiopathologic features in patients with resected lung adenocarcinoma. Identifying genomic alterations could help to predict the prognosis of early-stage lung adenocarcinoma.

Identifiants

DOI: 10.21037/jtd-20-1716 PMID: 33209369 PMC: PMC7656340
pubmed: 33209369
doi: 10.21037/jtd-20-1716
pii: jtd-12-10-5357
pmc: PMC7656340
doi:

Types de publication

Journal Article

Langues

eng

Pagination

5357-5368

Informations de copyright

2020 Journal of Thoracic Disease. All rights reserved.

Déclaration de conflit d'intérêts

Conflicts of Interests: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/jtd-20-1716). The authors have no conflicts of interest to declare.

Références

Radiology. 2016 Jul;280(1):271-80
pubmed: 26937803
Ann Thorac Surg. 2016 Feb;101(2):473-80
pubmed: 26454747
ESMO Open. 2018 Sep 17;3(6):e000419
pubmed: 30245863
N Engl J Med. 2017 Aug 31;377(9):829-838
pubmed: 28586279
Radiology. 2017 Jul;284(1):228-243
pubmed: 28240562
Ann Oncol. 2015 Jan;26(1):238-244
pubmed: 25344360
JAMA. 2014 May 21;311(19):1998-2006
pubmed: 24846037
J Thorac Oncol. 2010 Mar;5(3):344-8
pubmed: 20087229
Transl Oncol. 2014 Oct 24;7(5):556-69
pubmed: 25389451
N Engl J Med. 2009 Sep 3;361(10):947-57
pubmed: 19692680
Eur J Radiol. 2016 Nov;85(11):1934-1940
pubmed: 27776643
N Engl J Med. 2011 Aug 4;365(5):395-409
pubmed: 21714641
Eur Radiol. 2016 Nov;26(11):4141-4147
pubmed: 27027313
Exp Ther Med. 2015 Jun;9(6):2095-2103
pubmed: 26136941
Chest. 2017 Jan;151(1):193-203
pubmed: 27780786
Lung Cancer. 2018 Jan;115:28-33
pubmed: 29290258
J Thorac Oncol. 2012 Feb;7(2):355-64
pubmed: 22157369
J Thorac Oncol. 2009 Dec;4(12):1490-5
pubmed: 19844187
Eur Respir J. 2019 Aug 29;54(2):
pubmed: 31048349
Lung Cancer. 2012 Aug;77(2):319-25
pubmed: 22483782
Radiology. 2008 Mar;246(3):697-722
pubmed: 18195376
Lancet Oncol. 2008 Oct;9(10):962-72
pubmed: 18804418
AJR Am J Roentgenol. 2001 Dec;177(6):1417-22
pubmed: 11717098
Ann Oncol. 2013 Jan;24(1):67-74
pubmed: 23002278
J Thorac Oncol. 2011 Feb;6(2):244-85
pubmed: 21252716
J Thorac Oncol. 2006 Jun;1(5):413-6
pubmed: 17409892
Eur Radiol. 2016 Jan;26(1):32-42
pubmed: 25956936
J Clin Oncol. 2013 May 20;31(15):1858-65
pubmed: 23589544
J Thorac Oncol. 2011 Mar;6(3):466-72
pubmed: 21258247
Insights Imaging. 2018 Feb;9(1):73-86
pubmed: 29143191
J Pathol Transl Med. 2016 May;50(3):197-203
pubmed: 27086595
Sci Rep. 2018 May 16;8(1):7691
pubmed: 29769567
Lancet Oncol. 2011 Oct;12(11):1004-12
pubmed: 21933749
Ann Thorac Cardiovasc Surg. 2015;21(2):102-8
pubmed: 24899136
Chest. 2013 Jan;143(1):172-178
pubmed: 22797081

Auteurs

Yeonseok Choi (Y)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Ki-Hwan Kim (KH)

Department of Radiology, Myongji Hospital, Goyang, South Korea.

Byeong-Ho Jeong (BH)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Kyung-Jong Lee (KJ)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Hojoong Kim (H)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

O Jung Kwon (OJ)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Jhingook Kim (J)

Department of Thoracic and Cardiovascular Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Yoon-La Choi (YL)

Department of Pathology and Translational Genomics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Ho Yun Lee (HY)

Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, Seoul, South Korea.

Sang-Won Um (SW)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Classifications MeSH