Loss of Adenylyl Cyclase 6 in Leptin Receptor-Expressing Stromal Cells Attenuates Loading-Induced Endosteal Bone Formation.
ADENYLYL CYCLASE 6
BONE ADAPTATION
IN VIVO MECHANICAL LOADING
MECHANOBIOLOGY
STEM CELLS
Journal
JBMR plus
ISSN: 2473-4039
Titre abrégé: JBMR Plus
Pays: England
ID NLM: 101707013
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
31
07
2020
accepted:
27
08
2020
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Bone marrow stromal/stem cells represent a quiescent cell population that replenish the osteoblast bone-forming cell pool with age and in response to injury, maintaining bone mass and repair. A potent mediator of stromal/stem cell differentiation in vitro and bone formation in vivo is physical loading, yet it still remains unclear whether loading-induced bone formation requires the osteogenic differentiation of these resident stromal/stem cells. Therefore, in this study, we utilized the leptin receptor (LepR) to identify and trace the contribution of bone marrow stromal cells to mechanoadaptation of bone in vivo. Twelve-week-old
Identifiants
pubmed: 33210061
doi: 10.1002/jbm4.10408
pii: JBM410408
pmc: PMC7657397
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e10408Subventions
Organisme : Versus Arthritis
ID : 20581
Pays : United Kingdom
Informations de copyright
© 2020 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research.
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