Analysis of brain atrophy and local gene expression in genetic frontotemporal dementia.
Frontotemporal dementia
astrocytes
atrophy
gene expression
imaging genetics
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
entrez:
19
11
2020
pubmed:
20
11
2020
medline:
20
11
2020
Statut:
epublish
Résumé
Frontotemporal dementia is a heterogeneous neurodegenerative disorder characterized by neuronal loss in the frontal and temporal lobes. Despite progress in understanding which genes are associated with the aetiology of frontotemporal dementia, the biological basis of how mutations in these genes lead to cell loss in specific cortical regions remains unclear. In this work we combined gene expression data for 16,772 genes from the Allen Institute for Brain Science atlas with brain maps of gray matter atrophy in symptomatic
Identifiants
pubmed: 33210084
doi: 10.1093/braincomms/fcaa122
pmc: PMC7667525
mid: EMS94121
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Medical Research Council
ID : MR/L016311/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/J009482/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M023664/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M008525/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N008324/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T046015/1
Pays : United Kingdom
Investigateurs
Caroline Greaves
(C)
Georgia Peakman
(G)
Rachelle Shafei
(R)
Emily Todd
(E)
Martin N. Rossor
(MN)
Jason D. Warren
(JD)
Nick C. Fox
(NC)
Henrik Zetterberg
(H)
Rita Guerreiro
(R)
Jose Bras
(J)
Jennifer Nicholas
(J)
Simon Mead
(S)
Lize Jiskoot
(L)
Lieke Meeter
(L)
Jessica Panman
(J)
Janne M. Papma
(JM)
Rick van Minkelen
(R)
Yolanda Pijnenburg
(Y)
Myriam Barandiaran
(M)
Begoa Indakoetxea
(B)
Alazne Gabilondo
(A)
Mikel Tainta
(M)
Maria de Arriba
(M)
Ana Gorostidi
(A)
Miren Zulaica
(M)
Jorge Villanua
(J)
Zigor Diaz
(Z)
Sergi Borrego-Ecija
(S)
Jaume Olives
(J)
Albert Lladó
(A)
Mircea Balasa
(M)
Anna Antonell
(A)
Nuria Bargallo
(N)
Enrico Premi
(E)
Maura Cosseddu
(M)
Stefano Gazzina
(S)
Alessandro Padovani
(A)
Roberto Gasparotti
(R)
Silvana Archetti
(S)
Sandra Black
(S)
Sara Mitchell
(S)
Ekaterina Rogaeva
(E)
Morris Freedman
(M)
Ron Keren
(R)
David Tang-Wai
(D)
Linn Öijerstedt
(L)
Christin Andersson
(C)
Vesna Jelic
(V)
Hakan Thonberg
(H)
Andrea Arighi
(A)
Chiara Fengolio
(C)
Elio Scarpini
(E)
Giorgio Fumagalli
(G)
Thomas Cope
(T)
Carolyn Timberlake
(C)
Timothy Rittman
(T)
Christen Shoesmith
(C)
Robart Bartha
(R)
Rosa Rademakers
(R)
Carlo Wilke
(C)
Hans-Otto Karnarth
(HO)
Benjamin Bender
(B)
Rose Bruffaerts
(R)
Philip Van Damme
(P)
Mathieu Vandenbulcke
(M)
Catarina B. Ferreira
(CB)
Gabriel Miltenberger
(G)
Carolina Maruta
(C)
Ana Verdelho
(A)
Sónia Afonso
(S)
Ricardo Taipa
(R)
Paola Caroppo
(P)
Giuseppe Di Fede
(G)
Giorgio Giaccone
(G)
Sara Prioni
(S)
Veronica Redaelli
(V)
Giacomina Rossi
(G)
Pietro Tiraboschi
(P)
Diana Duro
(D)
Maria Rosario Almeida
(MR)
Miguel Castelo-Branco
(M)
Maria João Leitão
(M)
Miguel Tabuas-Pereira
(M)
Beatriz Santiago
(B)
Serge Gauthier
(S)
Pedro Rosa-Neto
(P)
Michele Veldsman
(M)
Paul Thompson
(P)
Tobias Langheinrich
(T)
Catharina Prix
(C)
Tobias Hoegen
(T)
Elisabeth Wlasich
(E)
Sandra Loosli
(S)
Sonja Schonecker
(S)
Elisa Semler
(E)
Sarah Anderl-Straub
(S)
Luisa Benussi
(L)
Giuliano Binetti
(G)
Michela Pievani
(M)
Gemma Lombardi
(G)
Benedetta Nacmias
(B)
Camilla Ferrari
(C)
Valentina Bessi
(V)
Cristina Polito
(C)
Déclaration de conflit d'intérêts
Competing Interests Nothing to declare.
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