Alteration of miRNA Biogenesis Regulating Proteins in the Human Microglial Cell Line HMC-3 After Ischemic Stress.
Argonaute Proteins
/ metabolism
Brain Ischemia
/ genetics
Cell Line
DNA Helicases
/ metabolism
Gene Expression Regulation
/ drug effects
Glucose
/ deficiency
Humans
Hydrogen Peroxide
/ toxicity
MicroRNAs
/ biosynthesis
Microglia
/ drug effects
Models, Biological
Oxidative Stress
/ drug effects
Oxygen
Poly-ADP-Ribose Binding Proteins
/ metabolism
RNA Helicases
/ metabolism
RNA Processing, Post-Transcriptional
/ drug effects
RNA Recognition Motif Proteins
/ metabolism
Ribonuclease III
/ metabolism
Stress, Physiological
/ drug effects
AGO2
Hydrogen peroxide
Hypoxia
Ischemia
OGD
miRNA biogenesis
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
received:
26
08
2020
accepted:
12
11
2020
pubmed:
20
11
2020
medline:
28
10
2021
entrez:
19
11
2020
Statut:
ppublish
Résumé
MicroRNAs (miRNA) are small noncoding sequences that control apoptosis, proliferation, and neuroinflammatory pathways in microglia cells. The expression of distinct miRNAs is altered after ischemia in the brain. Only minor information is available about the biogenesis and maturation of miRNAs after ischemia. We aimed at examining the impact of oxygen-glucose deprivation (OGD) and hydrogen peroxide (H
Identifiants
pubmed: 33210205
doi: 10.1007/s12035-020-02210-y
pii: 10.1007/s12035-020-02210-y
doi:
Substances chimiques
AGO2 protein, human
0
Argonaute Proteins
0
MicroRNAs
0
Poly-ADP-Ribose Binding Proteins
0
RNA Recognition Motif Proteins
0
Hydrogen Peroxide
BBX060AN9V
DROSHA protein, human
EC 3.1.26.3
Ribonuclease III
EC 3.1.26.3
DNA Helicases
EC 3.6.4.-
G3BP1 protein, human
EC 3.6.4.12
RNA Helicases
EC 3.6.4.13
Glucose
IY9XDZ35W2
Oxygen
S88TT14065
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1535-1549Subventions
Organisme : Medizinische Fakultät, RWTH Aachen University
ID : START-117/18
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