Is mapping the BCG vaccine-induced immune responses the key to improving the efficacy against tuberculosis?
immunology
tuberculosis
vaccine
Journal
Journal of internal medicine
ISSN: 1365-2796
Titre abrégé: J Intern Med
Pays: England
ID NLM: 8904841
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
29
06
2020
revised:
31
08
2020
accepted:
07
09
2020
pubmed:
20
11
2020
medline:
23
2
2021
entrez:
19
11
2020
Statut:
ppublish
Résumé
In recent years, the century-old Mycobacterium bovis Bacillus Calmette-Guérin (BCG) vaccine against tuberculosis (TB) has been re-evaluated for its capacity to stem the global tide of TB. There is increasing evidence that the efficacy of BCG can be improved by the modified administration methods and schedules. Here, we first discuss recent approaches of vaccine administration, revaccination or boosting that have been used to try to improve the efficacy of BCG against TB. We then dive deeper into studies investigating the immune correlates of protection and describe studies that have investigated BCG-specific T-cell responses and the influence of environmental exposures. These studies all highlight that there is still a lot to learn about the immune response induced by BCG, both in terms of phenotype and specificity, which has been surprisingly understudied. We argue that several critical gaps in knowledge exist and must be addressed by future research to rationally improve the efficacy of BCG, including comprehensive, proteome-wide understanding of the epitopes derived from BCG recognized by BCG-vaccinated individuals, the phenotype of responding antigen-specific T cells and how previous exposure to environmental mycobacteria affect these parameters and thus influence vaccine efficacy. The development of modern techniques allows us to answer some of these questions to better understand how BCG works in terms of both protection against TB and the immune response that it triggers.
Identifiants
pubmed: 33210407
doi: 10.1111/joim.13191
pmc: PMC9432460
mid: NIHMS1640384
doi:
Substances chimiques
BCG Vaccine
0
Epitopes, T-Lymphocyte
0
Proteome
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
651-660Subventions
Organisme : NIAID NIH HHS
ID : 75N93019C00067
Pays : United States
Informations de copyright
© 2020 The Association for the Publication of the Journal of Internal Medicine.
Références
Front Immunol. 2018 Feb 05;9:121
pubmed: 29459859
J Infect Dis. 2011 Jun 15;203(12):1832-43
pubmed: 21606542
Lancet. 2002 Apr 20;359(9315):1393-401
pubmed: 11978337
Nat Commun. 2016 Apr 12;7:11290
pubmed: 27068708
J Immunol. 1997 Feb 15;158(4):1949-55
pubmed: 9029137
Trans R Soc Trop Med Hyg. 2015 Mar;109(3):175-81
pubmed: 25636950
PLoS One. 2010 Jun 28;5(6):e11319
pubmed: 20596522
Lancet. 2013 Mar 23;381(9871):1021-8
pubmed: 23391465
J Immunol. 2016 Aug 15;197(4):1100-1110
pubmed: 27412415
PLoS Pathog. 2016 May 06;12(5):e1005614
pubmed: 27153120
PLoS Pathog. 2019 Mar 4;15(3):e1007643
pubmed: 30830940
Ann N Y Acad Sci. 2005 Dec;1062:69-78
pubmed: 16461790
Proc Natl Acad Sci U S A. 2015 Jan 13;112(2):E147-55
pubmed: 25548174
JAMA. 2004 May 5;291(17):2086-91
pubmed: 15126436
Clin Vaccine Immunol. 2015 Sep;22(9):992-1003
pubmed: 26108288
Lancet. 2005 Oct 8;366(9493):1290-5
pubmed: 16214599
Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5596-601
pubmed: 17372194
Clin Exp Immunol. 2012 Sep;169(3):213-9
pubmed: 22861360
Front Immunol. 2017 Sep 19;8:1147
pubmed: 28974949
J R Soc Interface. 2013 Jul 31;10(87):20130365
pubmed: 23904584
Clin Exp Immunol. 2000 Sep;121(3):417-25
pubmed: 10971505
Vaccine. 2014 Jun 24;32(30):3759-64
pubmed: 24852722
Int J Tuberc Lung Dis. 1998 Mar;2(3):200-7
pubmed: 9526191
Am J Respir Crit Care Med. 2010 Oct 15;182(8):1073-9
pubmed: 20558627
Infect Immun. 2000 Feb;68(2):621-9
pubmed: 10639425
Hum Immunol. 2010 Jul;71(7):692-6
pubmed: 20353805
AIDS Res Hum Retroviruses. 2002 Sep 1;18(13):969-75
pubmed: 12230939
Int J Tuberc Lung Dis. 2003 Apr;7(4):399-402
pubmed: 12729348
J Immunol. 2018 May 1;200(9):3283-3290
pubmed: 29602771
Science. 1999 May 28;284(5419):1520-3
pubmed: 10348738
Nature. 2020 Jan;577(7788):95-102
pubmed: 31894150
Infect Immun. 2002 Jun;70(6):3026-32
pubmed: 12010994
J Immunol. 2014 Sep 15;193(6):2931-40
pubmed: 25092889
Lancet. 2006 Apr 8;367(9517):1173-80
pubmed: 16616560
Am J Respir Crit Care Med. 2007 Aug 1;176(3):306-13
pubmed: 17507546
Cell. 2014 May 22;157(5):1073-87
pubmed: 24855945
Mucosal Immunol. 2018 Mar;11(2):486-495
pubmed: 28853442
J Immunol. 2006 Oct 15;177(8):5647-51
pubmed: 17015753
Clin Infect Dis. 2014 Feb;58(4):470-80
pubmed: 24336911
PLoS Pathog. 2013 Jan;9(1):e1003130
pubmed: 23358848
Lancet Infect Dis. 2016 Feb;16(2):219-26
pubmed: 26603173
Lancet. 1996 Jul 6;348(9019):17-24
pubmed: 8691924
N Engl J Med. 2018 Jul 12;379(2):138-149
pubmed: 29996082
Nat Med. 2019 Feb;25(2):255-262
pubmed: 30664782
Immunohorizons. 2020 Jun 4;4(6):292-307
pubmed: 32499216
Front Immunol. 2020 Feb 27;11:316
pubmed: 32174919
Tuberculosis (Edinb). 2010 Nov;90(6):329-32
pubmed: 20659816
Health Technol Assess. 2013 Sep;17(37):1-372, v-vi
pubmed: 24021245
Infect Immun. 1995 Apr;63(4):1491-7
pubmed: 7890415
Lancet Infect Dis. 2018 Aug;18(8):828-829
pubmed: 30064668
Front Immunol. 2017 Sep 13;8:1134
pubmed: 28955344
EClinicalMedicine. 2020 Mar 18;21:100313
pubmed: 32382714
FEMS Microbiol Rev. 2008 Aug;32(5):821-41
pubmed: 18616602
Lancet. 1995 Nov 18;346(8986):1339-45
pubmed: 7475776
Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12434-9
pubmed: 17640915
Pediatrics. 1995 Jul;96(1 Pt 1):29-35
pubmed: 7596718
Nat Rev Microbiol. 2005 Aug;3(8):656-62
pubmed: 16012514
JCI Insight. 2019 Dec 19;4(24):
pubmed: 31743110
Infect Immun. 2002 Feb;70(2):672-8
pubmed: 11796598
PLoS Pathog. 2018 Oct 12;14(10):e1007305
pubmed: 30312351
J Infect Dis. 2019 Aug 30;220(7):1091-1098
pubmed: 31165861
Nat Med. 2004 Nov;10(11):1240-4
pubmed: 15502839
Eur J Immunol. 2009 Mar;39(3):723-9
pubmed: 19224636
J Immunol. 2008 Mar 1;180(5):3569-77
pubmed: 18292584
Infect Immun. 2003 Jan;71(1):483-93
pubmed: 12496199