The Brain-gut Axis-where are we now and how can we Modulate these Connections?
Traumatic brain injury
cells interactions
immunomodulation.
microbiome
secondary brain damage
trauma
Journal
Current neuropharmacology
ISSN: 1875-6190
Titre abrégé: Curr Neuropharmacol
Pays: United Arab Emirates
ID NLM: 101157239
Informations de publication
Date de publication:
2021
2021
Historique:
received:
21
07
2020
revised:
28
09
2020
accepted:
31
10
2020
pubmed:
21
11
2020
medline:
6
11
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
A traumatic brain injury (TBI) initiates an inflammatory response with molecular cascades triggered by the presence of necrotic debris, including damaged myelin, hemorrhages and injured neuronal cells. Molecular cascades prominent in TBI-induced inflammation include the release of an excess of proinflammatory cytokines and angiogenic factors, the degradation of tight junctions (TJs), cytoskeletal rearrangements and leukocyte and protein extravasation promoted by increased expression of adhesion molecules. The brain-gut axis consists of a complex network involving neuroendocrine and immunological signaling pathways and bi-directional neural mechanisms. Importantly, modifying the gut microbiome alters this axis, and in turn may influence brain injury and neuroinflammatory processes. In recent years it has been demonstrated that the activity and composition of the gastrointestinal (GI) microbiome population influences the brain through all of above-mentioned pathways affecting homeostasis of the central nervous system (CNS). The GI microbiome is involved in the modulation of cellular and molecular processes which are fundamental to the progression of TBI-induced pathologies, including neuroinflammation, abnormal blood brain barrier (BBB) permeability, immune system responses, microglial activation, and mitochondrial dysfunction. It has been postulated that interaction between the brain and gut microbiome occurs mainly via the enteric nervous system and the vagus nerve through neuroactive compounds including serotonin or dopamine and activation by bacterial metabolites including endotoxin, neurotransmitters, neurotrophic factors, and cytokines. In recent years the multifactorial impact of selected immunomodulatory drugs on immune processes occurring in the CNS and involving the brain-gut axis has been under intensive investigation.
Identifiants
pubmed: 33213347
pii: CN-EPUB-111671
doi: 10.2174/1570159X18666201119155535
pmc: PMC8719292
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1164-1177Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Références
Exp Neurol. 2009 Aug;218(2):381-9
pubmed: 19477175
Front Neurol. 2019 Aug 16;10:875
pubmed: 31474930
J Neurotrauma. 2009 Aug;26(8):1353-9
pubmed: 19344293
Acta Pharmacol Sin. 2001 Mar;22(3):225-30
pubmed: 11742568
Toxicol Lett. 2018 May 1;287:23-30
pubmed: 29391279
J Trauma. 2010 May;68(5):1059-64
pubmed: 20453760
Front Microbiol. 2019 Oct 31;10:2473
pubmed: 31736912
Brain Res. 2016 Jul 1;1642:180-188
pubmed: 27037183
Sci Transl Med. 2014 Nov 19;6(263):263ra158
pubmed: 25411471
Mol Psychiatry. 2014 Feb;19(2):146-8
pubmed: 23689536
Front Neurosci. 2019 Mar 19;13:217
pubmed: 30941005
Stem Cells. 2017 Apr;35(4):1065-1079
pubmed: 27800660
Diabetes Care. 2017 Jan;40(1):54-62
pubmed: 27999002
Exp Neurol. 2014 Jul;257:106-13
pubmed: 24792639
Brain Behav Immun. 2017 Oct;65:57-67
pubmed: 28606462
J Orthop Surg Res. 2019 Jul 2;14(1):199
pubmed: 31266512
J Neurotrauma. 2018 Jan 15;35(2):341-352
pubmed: 28978285
J Pineal Res. 2019 Aug;67(1):e12574
pubmed: 30929267
Nutrients. 2015 Apr 14;7(4):2839-49
pubmed: 25875123
Arch Pharm Res. 2014 Mar;37(3):371-8
pubmed: 23771520
Stem Cells Dev. 2014 Aug 15;23(16):1831-43
pubmed: 24803072
Lancet. 2003 Feb 8;361(9356):512-9
pubmed: 12583961
Drug Des Devel Ther. 2018 Aug 10;12:2497-2508
pubmed: 30127597
J Neurol. 2019 Aug;266(8):1988-1997
pubmed: 31093755
J Trauma Acute Care Surg. 2019 Apr;86(4):573-582
pubmed: 30633104
Sci Rep. 2015 Sep 23;5:14405
pubmed: 26396057
Front Microbiol. 2020 Feb 21;11:219
pubmed: 32153527
J Physiol Paris. 1999 Dec;93(6):505-12
pubmed: 10672997
Brain Res Bull. 2018 Jun;140:154-161
pubmed: 29698747
Stem Cells Dev. 2006 Jun;15(3):407-21
pubmed: 16846377
PLoS One. 2016 Oct 25;11(10):e0164237
pubmed: 27780244
J Psychiatr Res. 2020 Mar;122:70-78
pubmed: 31927268
J Cereb Blood Flow Metab. 2016 May;36(5):891-8
pubmed: 26945017
Poult Sci. 2017 Aug 1;96(8):2942-2949
pubmed: 28431176
NeuroRehabilitation. 2004;19(1):25-35
pubmed: 14988585
Neuropathology. 2007 Aug;27(4):355-63
pubmed: 17899689
Clin Transl Med. 2019 Dec 23;8(1):31
pubmed: 31872304
Regul Pept. 2010 Feb 25;160(1-3):26-32
pubmed: 19931318
Nat Med. 2018 Dec;24(12):1919-1929
pubmed: 30397356
Prog Neurobiol. 2018 Apr - May;163-164:144-171
pubmed: 28987927
Gut. 2014 May;63(5):727-35
pubmed: 23804561
CNS Neurosci Ther. 2020 Jun;26(6):603-615
pubmed: 32356605
Sci Rep. 2020 Mar 25;10(1):5397
pubmed: 32214138
Curr Pharm Biotechnol. 2015;16(8):733-7
pubmed: 25941888
J Neuroinflammation. 2019 Jan 31;16(1):21
pubmed: 30704505
Transl Psychiatry. 2016 Apr 05;6:e774
pubmed: 27045844
Microorganisms. 2019 Jan 10;7(1):
pubmed: 30634578
Cells. 2020 Apr 10;9(4):
pubmed: 32290112
Curr Pharm Des. 2011;17(16):1612-32
pubmed: 21548867
Shock. 2019 Aug;52(2):240-248
pubmed: 29953417
Sci Rep. 2019 Apr 5;9(1):5674
pubmed: 30952961
Front Immunol. 2018 Nov 27;9:2757
pubmed: 30546361
Mol Nutr Food Res. 2010 Jul;54 Suppl 2:S205-13
pubmed: 20087858
Neurogastroenterol Motil. 2018 May;30(5):e13260
pubmed: 29193450
PLoS One. 2020 Jan 15;15(1):e0226128
pubmed: 31940312
Brain Behav Immun. 2017 Nov;66:31-44
pubmed: 28526435
Neurochem Int. 2015 Dec;91:46-54
pubmed: 26527380
J Physiol Pharmacol. 2013 Oct;64(5):597-612
pubmed: 24304574
Neuropharmacology. 2019 Feb;145(Pt B):145-152
pubmed: 29885419
J Neurotrauma. 2017 Jan 1;34(1):192-203
pubmed: 26757855
World J Gastroenterol. 2003 Dec;9(12):2776-81
pubmed: 14669332
Mitochondrion. 2018 Mar;39:20-25
pubmed: 28838618
PLoS One. 2020 Mar 19;15(3):e0226584
pubmed: 32191733
Biomed Pharmacother. 2018 Oct;106:349-354
pubmed: 29966980
Cell. 2014 Mar 27;157(1):121-41
pubmed: 24679531
Immune Netw. 2018 Aug 13;18(4):e27
pubmed: 30181915
J Neurosci Res. 2003 Sep 15;73(6):778-86
pubmed: 12949903
J Neurotrauma. 2016 Aug 15;33(16):1492-500
pubmed: 26542887
Nat Rev Gastroenterol Hepatol. 2019 Nov;16(11):656-661
pubmed: 31562390
Stem Cells. 2007 Nov;25(11):2777-85
pubmed: 17641243
BMC Microbiol. 2018 Dec 22;18(1):222
pubmed: 30579332
Brain Behav. 2020 Aug;10(8):e01726
pubmed: 32558293
Trauma Surg Acute Care Open. 2017 Oct 23;2(1):e000108
pubmed: 29766103
Science. 2005 Mar 25;307(5717):1915-20
pubmed: 15790844
Oxid Med Cell Longev. 2017;2017:6057609
pubmed: 28785377
Int J Mol Sci. 2019 May 14;20(10):
pubmed: 31091773
J Neurosci. 2015 Jul 29;35(30):10821-30
pubmed: 26224864
Nat Neurosci. 2015 Jul;18(7):965-77
pubmed: 26030851
J Cell Mol Med. 2018 Feb;22(2):883-891
pubmed: 29205806
Shock. 2019 Sep;52(3):318-325
pubmed: 30335675
Dig Dis Sci. 1996 Aug;41(8):1604-14
pubmed: 8769287
Folia Neuropathol. 2013;51(3):189-202
pubmed: 24114636
Neurotherapeutics. 2016 Oct;13(4):762-774
pubmed: 27714645
J Neurotrauma. 2019 Sep 15;36(18):2646-2664
pubmed: 30693824
J Cell Physiol. 2011 Oct;226(10):2562-70
pubmed: 21792913
Transl Neurodegener. 2015 Oct 12;4:19
pubmed: 26464797
PLoS One. 2020 Mar 26;15(3):e0230200
pubmed: 32214324
Oncotarget. 2017 Dec 12;9(1):866-880
pubmed: 29416662
Cell Host Microbe. 2014 Jun 11;15(6):792-8
pubmed: 24882705
Acta Pharmacol Sin. 2005 Aug;26(8):934-42
pubmed: 16038625
PLoS One. 2016 May 06;11(5):e0154427
pubmed: 27152411
Genome Med. 2016 Apr 13;8(1):39
pubmed: 27074706
J Agric Food Chem. 2012 Feb 29;60(8):1937-44
pubmed: 22300539
J Neurosurg. 2010 Sep;113(3):564-70
pubmed: 20113156
Appl Environ Microbiol. 2014 Oct;80(19):5935-43
pubmed: 25038099
Biomedicines. 2020 Sep 23;8(10):
pubmed: 32977430
Proc Natl Acad Sci U S A. 2017 Oct 3;114(40):10713-10718
pubmed: 28893978
Neurocrit Care. 2017 Feb;26(1):122-132
pubmed: 27406816
Nat Prod Res. 2015;29(4):374-7
pubmed: 25103916
Cell. 2015 Apr 9;161(2):264-76
pubmed: 25860609
Neurochem Int. 2016 Oct;99:110-132
pubmed: 27346602
Stem Cells Transl Med. 2018 Jun;7(6):456-467
pubmed: 29635868
Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10747-52
pubmed: 23754423
Front Microbiol. 2019 Sep 04;10:1947
pubmed: 31551944
Stem Cell Res Ther. 2017 Sep 29;8(1):213
pubmed: 28962644
Med Clin North Am. 2020 Mar;104(2):213-238
pubmed: 32035565
PLoS One. 2012;7(7):e41229
pubmed: 22815977
Curr Opin Neurobiol. 2020 Jun;62:92-101
pubmed: 32066076
Nat Med. 2017 Jul;23(7):850-858
pubmed: 28530702
Chin Med J (Engl). 2016 5th Oct;129(19):2373-80
pubmed: 27647198
Transl Psychiatry. 2016 Oct 25;6(10):e927
pubmed: 27779624
Curr Neuropharmacol. 2016;14(8):857-865
pubmed: 27138887
Curr Pharm Biotechnol. 2014;15(6):583-8
pubmed: 25213366
Exp Neurol. 2016 Jan;275 Pt 3:381-388
pubmed: 26091850
Folia Neuropathol. 2019;57(1):41-50
pubmed: 31038187
Acta Neurochir (Wien). 2006 Feb;148(2):181-93; discussion 193-4
pubmed: 16362181
J Neuroinflammation. 2017 Aug 23;14(1):167
pubmed: 28835272
J Nutr Biochem. 2017 Nov;49:133-140
pubmed: 28950154
Cardiovasc Diagn Ther. 2019 Dec;9(6):545-560
pubmed: 32038944
Inflammopharmacology. 1999;7(1):1-14
pubmed: 17657443
Mol Med Rep. 2018 Jun;17(6):7859-7865
pubmed: 29620218
Inflammopharmacology. 2006 Dec;14(5-6):214-21
pubmed: 17186181
Restor Neurol Neurosci. 2015;33(2):143-57
pubmed: 25588463
PLoS One. 2013 Dec 18;8(12):e83934
pubmed: 24367620
Drug Des Devel Ther. 2018 Apr 16;12:845-853
pubmed: 29713142
Front Neurol. 2019 Mar 08;10:198
pubmed: 30906278
PLoS One. 2014 Apr 10;9(4):e94699
pubmed: 24722235
Free Radic Biol Med. 2019 Feb 1;131:345-355
pubmed: 30553970
Sci Rep. 2020 Feb 10;10(1):2232
pubmed: 32042047
Circulation. 2019 Jan 29;139(5):647-659
pubmed: 30586712
Dis Model Mech. 2009 Jan-Feb;2(1-2):23-38
pubmed: 19132123
Mol Nutr Food Res. 2020 Jan;64(1):e1900789
pubmed: 31755244
J Cereb Blood Flow Metab. 2008 Apr;28(4):684-96
pubmed: 18183032
Cell. 2017 Jun 15;169(7):1249-1262.e13
pubmed: 28622510
Neurogastroenterol Motil. 2011 Mar;23(3):255-64, e119
pubmed: 21054680
J Physiol. 2004 Jul 1;558(Pt 1):263-75
pubmed: 15133062
Cell Mol Gastroenterol Hepatol. 2018 Apr 12;6(2):133-148
pubmed: 30023410
Int J Mol Sci. 2013 Apr 24;14(5):8869-89
pubmed: 23615475
J Cell Physiol. 2018 Jul;233(7):5160-5169
pubmed: 29150951
Crit Care. 2011;15(6):R290
pubmed: 22136422
Brain Behav Immun. 2016 Oct;57:10-20
pubmed: 27060191
Neuroscience. 2005;136(1):123-34
pubmed: 16198497
Neurotherapeutics. 2018 Jan;15(1):60-67
pubmed: 29101668
J Neurosci. 2016 Jul 13;36(28):7428-40
pubmed: 27413153
Nat Immunol. 2017 Jun;18(6):675-682
pubmed: 28436956
Nat Commun. 2017 Apr 04;8:15062
pubmed: 28375200
Eur J Pharmacol. 2005 Apr 11;512(2-3):173-9
pubmed: 15840402
Gut. 2013 Jan;62(1):146-58
pubmed: 22525886
J Clin Med. 2019 Sep 12;8(9):
pubmed: 31547411
J Neuroinflammation. 2019 May 8;16(1):95
pubmed: 31068207
NPJ Parkinsons Dis. 2017 Jan 11;3:3
pubmed: 28649603
Neuroscience. 2013 Jun 14;240:287-96
pubmed: 23500100
Cell Rep. 2016 May 31;15(9):1945-56
pubmed: 27210745
Transl Stroke Res. 2011 Dec;2(4):492-516
pubmed: 22299022