Immune cell composition in the endometrium of patients with a complete molar pregnancy: Effects on outcome.
Adult
Chorionic Gonadotropin
/ blood
Curettage
Disease Progression
Endometrium
/ cytology
Female
Flow Cytometry
Follow-Up Studies
Gestational Age
Humans
Hydatidiform Mole
/ blood
Immunophenotyping
Lymphocytes, Tumor-Infiltrating
/ immunology
Middle Aged
Natural Killer T-Cells
/ immunology
Pregnancy
Retrospective Studies
Uterine Neoplasms
/ blood
Young Adult
Complete hydatidiform mole
Multiplex immunohistochemistry
Natural killer t-like cells
Tumor infiltrating lymphocytes
Journal
Gynecologic oncology
ISSN: 1095-6859
Titre abrégé: Gynecol Oncol
Pays: United States
ID NLM: 0365304
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
05
09
2020
accepted:
06
11
2020
pubmed:
21
11
2020
medline:
1
7
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
In 15% of patients with complete hydatidiform mole (CHM), disease progresses to post-molar gestational trophoblastic neoplasia (GTN) after curettage. Tumor infiltrating lymphocytes (TILs) are essential in overcoming disease in many tumors. Infiltrating lymphocyte composition and density may influence trophoblast regression and development of post-molar GTN. We analyzed immune cell composition and density in curettaged endometrium of patients with CHM which spontaneously regressed, and of patients with CHM which progressed to post-molar GTN. Sixteen patients with CHM and spontaneous regression, and 16 patients with CHM which progressed to post-molar GTN were selected. Immune cell composition and density of natural killer (NK) cells, natural killer T (NKT)-like cells, Cytotoxic T cells, T-Regulatory and T-Helper cells, were determined by multiplex immunohistochemistry (mIHC). Curettaged endometrium of patients with CHM and spontaneous regression contained a slightly higher number of immune cells compared to patients with CHM which progressed to post-molar GTN. NKT-like cell density was significantly higher in patients with spontaneous regression compared to patients with CHM which progressed to post-molar GTN (483 ± 296 vs.295 ± 143 (mean ± SD), p = 0.03) respectively. NKT-like cell density in the spontaneous regression group was split in 'high' and 'low' (i.e. above and below the median number of NKT-like cells). In patients with high NKT-like cell density, hCG normalized earlier than in patients with low NKT-like cell density (9.5 weeks, (range 3.7-14) vs. 12.9 weeks, (range 8.6-17.9), p = 0.05). A high number of NKT-like cells in the endometrium of CHMs may contribute to spontaneous regression of molar trophoblast cells.
Identifiants
pubmed: 33213898
pii: S0090-8258(20)34113-5
doi: 10.1016/j.ygyno.2020.11.005
pii:
doi:
Substances chimiques
Chorionic Gonadotropin
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
450-456Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors have nothing to disclose.