Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
Animals
Binding Sites
Biological Coevolution
/ immunology
Broadly Neutralizing Antibodies
/ chemistry
CD4 Antigens
/ immunology
Cryoelectron Microscopy
Epitopes
/ immunology
HIV Antibodies
/ chemistry
HIV Envelope Protein gp120
/ genetics
HIV Infections
/ immunology
HIV-1
/ genetics
Humans
Macaca mulatta
Molecular Mimicry
/ immunology
Simian Immunodeficiency Virus
/ genetics
Virus Replication
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
08 01 2021
08 01 2021
Historique:
received:
10
06
2020
accepted:
09
11
2020
pubmed:
21
11
2020
medline:
17
2
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
Neutralizing antibodies elicited by HIV-1 coevolve with viral envelope proteins (Env) in distinctive patterns, in some cases acquiring substantial breadth. We report that primary HIV-1 envelope proteins-when expressed by simian-human immunodeficiency viruses in rhesus macaques-elicited patterns of Env-antibody coevolution very similar to those in humans, including conserved immunogenetic, structural, and chemical solutions to epitope recognition and precise Env-amino acid substitutions, insertions, and deletions leading to virus persistence. The structure of one rhesus antibody, capable of neutralizing 49% of a 208-strain panel, revealed a V2 apex mode of recognition like that of human broadly neutralizing antibodies (bNAbs) PGT145 and PCT64-35S. Another rhesus antibody bound the CD4 binding site by CD4 mimicry, mirroring human bNAbs 8ANC131, CH235, and VRC01. Virus-antibody coevolution in macaques can thus recapitulate developmental features of human bNAbs, thereby guiding HIV-1 immunogen design.
Identifiants
pubmed: 33214287
pii: science.abd2638
doi: 10.1126/science.abd2638
pmc: PMC8040783
mid: NIHMS1679978
pii:
doi:
Substances chimiques
Broadly Neutralizing Antibodies
0
CD4 Antigens
0
Epitopes
0
HIV Antibodies
0
HIV Envelope Protein gp120
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI100645
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103403
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007632
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI050529
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI150590
Pays : United States
Organisme : NIAID NIH HHS
ID : P30 AI045008
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140897
Pays : United States
Organisme : NIAID NIH HHS
ID : P01 AI131251
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI128832
Pays : United States
Organisme : NIH HHS
ID : U42 OD021458
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM103310
Pays : United States
Organisme : NIAID NIH HHS
ID : R61 AI161818
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI131331
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI160607
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI165080
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI050529
Pays : United States
Organisme : NIAID NIH HHS
ID : UM1 AI144371
Pays : United States
Organisme : NIH HHS
ID : P40 OD012217
Pays : United States
Informations de copyright
Copyright © 2021, American Association for the Advancement of Science.
Références
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W615-9
pubmed: 15215462
Nat Methods. 2015 Oct;12(10):943-6
pubmed: 26280328
J Virol. 2010 Dec;84(24):12995-3003
pubmed: 20881050
J Virol. 2005 Apr;79(8):5232-7
pubmed: 15795308
Nat Commun. 2019 Feb 13;10(1):721
pubmed: 30760721
mBio. 2015 Apr 21;6(2):
pubmed: 25900654
Viruses. 2015 Oct 21;7(10):5443-75
pubmed: 26506369
J Virol. 2000 Jan;74(1):254-63
pubmed: 10590113
Front Immunol. 2017 Oct 27;8:1407
pubmed: 29163486
N Engl J Med. 2016 Jun 2;374(22):2120-30
pubmed: 27192360
J Immunol Methods. 2012 Dec 14;386(1-2):10-21
pubmed: 22955212
J Struct Biol. 2007 Jan;157(1):38-46
pubmed: 16859925
Cell Rep. 2018 Jun 12;23(11):3249-3261
pubmed: 29898396
J Gen Virol. 1979 Jan;42(1):1-26
pubmed: 215703
J Struct Biol. 2009 Apr;166(1):95-102
pubmed: 19263523
Front Immunol. 2014 Apr 22;5:170
pubmed: 24795717
Cell Rep. 2018 Oct 23;25(4):893-908.e7
pubmed: 30355496
Nature. 1995 Jan 12;373(6510):123-6
pubmed: 7816094
PLoS Pathog. 2016 Jan 14;12(1):e1005369
pubmed: 26766578
Bioinformatics. 2006 Feb 15;22(4):438-44
pubmed: 16357034
Science. 2005 Jun 24;308(5730):1906-8
pubmed: 15860590
Nature. 2019 Jun;570(7762):468-473
pubmed: 31142836
PLoS Pathog. 2016 Dec 13;12(12):e1006114
pubmed: 27959955
Structure. 2011 May 11;19(5):691-9
pubmed: 21565703
Annu Rev Immunol. 2020 Apr 26;38:673-703
pubmed: 32340576
Sci Transl Med. 2019 Oct 30;11(516):
pubmed: 31666399
Nat Methods. 2017 Mar;14(3):290-296
pubmed: 28165473
J Struct Biol. 2016 Jan;193(1):1-12
pubmed: 26592709
J Struct Biol. 2015 Nov;192(2):216-21
pubmed: 26278980
Nature. 2002 Dec 12;420(6916):678-82
pubmed: 12478295
Immunity. 2015 Nov 17;43(5):959-73
pubmed: 26588781
Sci Immunol. 2017 Jan 27;2(7):
pubmed: 28783671
Virology. 2006 Feb 5;345(1):44-55
pubmed: 16242749
J Immunol Methods. 2014 Jul;409:131-46
pubmed: 24291345
Front Immunol. 2016 Sep 21;7:372
pubmed: 27708645
J Struct Biol. 2009 May;166(2):205-13
pubmed: 19374019
Science. 2011 Nov 25;334(6059):1097-103
pubmed: 21998254
Nat Protoc. 2013 Oct;8(10):1907-15
pubmed: 24030440
J Virol. 2019 Mar 5;93(6):
pubmed: 30567996
J Virol. 2013 Feb;87(3):1554-68
pubmed: 23175357
Nature. 2014 Oct 23;514(7523):455-61
pubmed: 25296255
Cell. 1986 Jun 6;45(5):637-48
pubmed: 2423250
Nat Commun. 2017 Nov 23;8(1):1732
pubmed: 29170366
Science. 2019 Dec 6;366(6470):
pubmed: 31806786
Nature. 1998 Jun 18;393(6686):705-11
pubmed: 9641684
Immunity. 2017 Jun 20;46(6):1073-1088.e6
pubmed: 28636956
J Virol. 2016 Mar 28;90(8):4017-4031
pubmed: 26842476
Cell. 2016 Apr 7;165(2):449-63
pubmed: 26949186
J Virol. 2010 Feb;84(3):1439-52
pubmed: 19939925
Cell Host Microbe. 2019 Jan 9;25(1):59-72.e8
pubmed: 30629920
J Virol. 2015 Oct 14;90(1):76-91
pubmed: 26468542
Nature. 1995 Jan 12;373(6510):117-22
pubmed: 7529365
J Virol. 2009 Feb;83(3):1240-59
pubmed: 19019969
J Exp Med. 2005 May 2;201(9):1407-19
pubmed: 15867093
PLoS Pathog. 2013;9(5):e1003342
pubmed: 23658524
J Virol. 2013 May;87(9):4882-94
pubmed: 23408621
J Exp Med. 2009 Jun 8;206(6):1253-72
pubmed: 19487423
Science. 2015 Jul 10;349(6244):191-5
pubmed: 26113642
J Immunol Methods. 2008 Jan 1;329(1-2):112-24
pubmed: 17996249
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298420
Proc Natl Acad Sci U S A. 2014 Jul 15;111(28):10275-80
pubmed: 24982157
Retrovirology. 2018 Sep 5;15(1):61
pubmed: 30185183
Virology. 2010 Jan 20;396(2):213-25
pubmed: 19913270
Commun Biol. 2018 Sep 5;1:134
pubmed: 30272013
Curr Protoc Cytom. 2010 Jul;Chapter 9:Unit 9.34
pubmed: 20578108
Elife. 2020 Oct 21;9:
pubmed: 33084569
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20125-9
pubmed: 22123961
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Science. 2011 Sep 16;333(6049):1633-7
pubmed: 21764753
PLoS Pathog. 2016 May 24;12(5):e1005674
pubmed: 27219002
PLoS Pathog. 2013 Sep;9(9):e1003618
pubmed: 24068931
Immunity. 2016 Jul 19;45(1):31-45
pubmed: 27438765
J Virol. 2011 Oct;85(19):9998-10009
pubmed: 21795340
Nat Protoc. 2009;4(3):372-84
pubmed: 19247287
Cell. 2014 Jul 31;158(3):481-91
pubmed: 25065977
Trends Microbiol. 2003 Dec;11(12):543-6
pubmed: 14659685
Virology. 2006 Jun 20;350(1):34-47
pubmed: 16616287
J Virol. 2007 Feb;81(3):1424-32
pubmed: 17121806
Immunity. 2015 Sep 15;43(3):591-604
pubmed: 26362266
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Immunity. 2017 Nov 21;47(5):990-1003.e9
pubmed: 29166592
Structure. 2019 Jan 2;27(1):196-206.e6
pubmed: 30471922
Cell Host Microbe. 2020 Apr 8;27(4):507-518
pubmed: 32272076
PLoS Pathog. 2009 May;5(5):e1000414
pubmed: 19424423
Cell Host Microbe. 2018 Jun 13;23(6):759-765.e6
pubmed: 29861171
Nat Commun. 2016 Dec 20;7:13642
pubmed: 27995928
AIDS. 2014 Jan 14;28(2):163-9
pubmed: 24361678
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
Nature. 2003 Mar 20;422(6929):307-12
pubmed: 12646921
Immunity. 2019 Mar 19;50(3):677-691.e13
pubmed: 30876875
Proc Natl Acad Sci U S A. 2016 Jun 14;113(24):E3413-22
pubmed: 27247400
Immunity. 2018 May 15;48(5):855-871
pubmed: 29768174
Viruses. 2020 Jan 31;12(2):
pubmed: 32023860
J Virol. 2018 Mar 28;92(8):
pubmed: 29367243
J Virol. 2014 Mar;88(5):2489-507
pubmed: 24352443
Curr HIV Res. 2018;16(1):21-28
pubmed: 29173180
Proc Natl Acad Sci U S A. 2008 May 27;105(21):7552-7
pubmed: 18490657
Science. 2019 Dec 6;366(6470):
pubmed: 31672916
Cell Rep. 2017 Dec 26;21(13):3681-3690
pubmed: 29281818
J Virol. 2003 Apr;77(8):5037-8
pubmed: 12663814
Immunity. 2013 Aug 22;39(2):245-58
pubmed: 23911655
Cell Rep. 2019 May 21;27(8):2426-2441.e6
pubmed: 31116986
J Struct Biol. 2005 Jul;151(1):41-60
pubmed: 15890530
Nat Methods. 2017 Apr;14(4):331-332
pubmed: 28250466
Immunity. 2014 Dec 18;41(6):909-18
pubmed: 25526306
Nat Biotechnol. 2012 May 07;30(5):423-33
pubmed: 22565972
Sci Transl Med. 2017 Mar 15;9(381):
pubmed: 28298421
Genome Res. 1998 Mar;8(3):175-85
pubmed: 9521921
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
J Virol. 2016 May 12;90(11):5231-5245
pubmed: 26984721
Nature. 2014 May 1;509(7498):55-62
pubmed: 24590074
Cell Rep. 2017 Apr 25;19(4):719-732
pubmed: 28445724
AIDS. 2018 Mar 13;32(5):555-563
pubmed: 29239895
J Virol Methods. 2009 Jun;158(1-2):171-9
pubmed: 19428587
Cell Rep. 2018 Feb 13;22(7):1798-1809
pubmed: 29444432
J Virol. 2012 Jul;86(14):7496-507
pubmed: 22553329
J Exp Med. 2009 Jun 8;206(6):1273-89
pubmed: 19487424
Nat Struct Mol Biol. 2016 Jan;23(1):81-90
pubmed: 26689967
Cell. 2019 Jul 25;178(3):567-584.e19
pubmed: 31348886
PLoS Pathog. 2012;8(5):e1002721
pubmed: 22693447
Nat Med. 2015 Nov;21(11):1332-6
pubmed: 26457756
Sci Transl Med. 2016 Apr 27;8(336):336ra62
pubmed: 27122615
Cell Rep. 2020 Apr 7;31(1):107488
pubmed: 32268107
Science. 2013 May 10;340(6133):751-6
pubmed: 23661761
Nat Commun. 2019 Jul 1;10(1):2898
pubmed: 31263112
Nat Immunol. 2018 Nov;19(11):1179-1188
pubmed: 30333615
Nature. 2013 Apr 25;496(7446):469-76
pubmed: 23552890
Nat Med. 1997 Feb;3(2):205-11
pubmed: 9018240
J Synchrotron Radiat. 2004 Jan 1;11(Pt 1):53-5
pubmed: 14646133
Science. 2010 Aug 13;329(5993):856-61
pubmed: 20616233
Curr Protoc Immunol. 2005 Jan;Chapter 12:Unit 12.11
pubmed: 18432938
J Struct Biol. 2012 Dec;180(3):519-30
pubmed: 23000701