Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation.
Journal
ACS medicinal chemistry letters
ISSN: 1948-5875
Titre abrégé: ACS Med Chem Lett
Pays: United States
ID NLM: 101521073
Informations de publication
Date de publication:
12 Nov 2020
12 Nov 2020
Historique:
received:
17
07
2020
accepted:
29
09
2020
entrez:
20
11
2020
pubmed:
21
11
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 isoform-selective inhibitors based on the X-ray crystal studies of the hit
Identifiants
pubmed: 33214839
doi: 10.1021/acsmedchemlett.0c00395
pmc: PMC7667836
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2268-2276Subventions
Organisme : NIGMS NIH HHS
ID : P30 GM124165
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM049758
Pays : United States
Organisme : NCRR NIH HHS
ID : S10 RR029205
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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