The Role of Social Reward and Corticostriatal Connectivity in Substance Use.
addiction
corticostriatal connectivity
neuroimaging
prospective risk
reward sensitivity
social reward
striatum
Journal
Journal of psychiatry and brain science
ISSN: 2398-385X
Titre abrégé: J Psychiatr Brain Sci
Pays: England
ID NLM: 101739159
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
20
11
2020
pubmed:
21
11
2020
medline:
21
11
2020
Statut:
ppublish
Résumé
This report describes an ongoing R03 grant that explores the links between trait reward sensitivity, substance use, and neural responses to social and nonsocial reward. Although previous research has shown that trait reward sensitivity and neural responses to reward are linked to substance use, whether this relationship is impacted by how people process social stimuli remains unclear. We are investigating these questions via a neuroimaging study with college-aged participants, using individual difference measures that examine the relation between substance use, social context, and trait reward sensitivity with tasks that measure reward anticipation, strategic behavior, social reward consumption, and the influence of social context on reward processing. We predict that substance use will be tied to distinct patterns of striatal dysfunction. Specifically, reward hyposensitive individuals will exhibit blunted striatal responses to social and non-social reward and enhanced connectivity with the orbitofrontal cortex; in contrast, reward hypersensitive individuals will exhibit enhanced striatal responses to social and non-social reward and blunted connectivity with the orbitofrontal cortex. We also will examine the relation between self-reported reward sensitivity, substance use, and striatal responses to social reward and social context. We predict that individuals reporting the highest levels of substance use will show exaggerated striatal responses to social reward and social context, independent of self-reported reward sensitivity. Examining corticostriatal responses to reward processing will help characterize the relation between reward sensitivity, social context and substance use while providing a foundation for understanding risk factors and isolating neurocognitive mechanisms that may be targeted to increase the efficacy of interventions.
Identifiants
pubmed: 33215046
doi: 10.20900/jpbs.20200024
pmc: PMC7673297
mid: NIHMS1642497
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIDA NIH HHS
ID : R03 DA046733
Pays : United States
Organisme : NIMH NIH HHS
ID : R15 MH122927
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD093912
Pays : United States
Déclaration de conflit d'intérêts
CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.
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