Cerebrovascular disease promotes tau pathology in Alzheimer's disease.
Alzheimer’s disease
cerebrovascular disease
plasma biomarkers
tau
white matter hyperintensities
Journal
Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
09
2019
revised:
02
07
2020
accepted:
07
07
2020
entrez:
20
11
2020
pubmed:
21
11
2020
medline:
21
11
2020
Statut:
epublish
Résumé
Small vessel cerebrovascular disease, visualized as white matter hyperintensities on T2-weighted magnetic resonance imaging, contributes to the clinical presentation of Alzheimer's disease. However, the extent to which cerebrovascular disease represents an independent pathognomonic feature of Alzheimer's disease or directly promotes Alzheimer's pathology is unclear. The purpose of this study was to examine the association between white matter hyperintensities and plasma levels of tau and to determine if white matter hyperintensities and tau levels interact to predict Alzheimer's disease diagnosis. To confirm that cerebrovascular disease promotes tau pathology, we examined tau fluid biomarker concentrations and pathology in a mouse model of ischaemic injury. Three hundred ninety-one participants from the Alzheimer's Disease Neuroimaging Initiative (74.5 ± 7.1 years of age) were included in this cross-sectional analysis. Participants had measurements of plasma total-tau, cerebrospinal fluid beta-amyloid, and white matter hyperintensities, and were diagnosed clinically as Alzheimer's disease (
Identifiants
pubmed: 33215083
doi: 10.1093/braincomms/fcaa132
pii: fcaa132
pmc: PMC7660042
doi:
Types de publication
Journal Article
Langues
eng
Pagination
fcaa132Subventions
Organisme : NIA NIH HHS
ID : K99 AG065506
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Informations de copyright
© The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain.
Références
J Cereb Blood Flow Metab. 2011 Apr;31(4):991-3
pubmed: 21206507
Acta Neuropathol. 2017 Sep;134(3):459-473
pubmed: 28638989
PLoS One. 2011;6(10):e25446
pubmed: 22022397
J Comp Neurol. 2019 Apr 1;527(5):985-998
pubmed: 30408165
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
Nat Med. 2020 Mar;26(3):387-397
pubmed: 32123386
Neurology. 2016 Oct 25;87(17):1827-1835
pubmed: 27694257
Alzheimers Dement. 2018 Apr;14(4):535-562
pubmed: 29653606
Lancet Neurol. 2013 Aug;12(8):822-38
pubmed: 23867200
PLoS One. 2013;8(3):e57503
pubmed: 23505432
Arch Neurol. 2012 Dec;69(12):1621-7
pubmed: 22945686
Ann Neurol. 2016 Jun;79(6):929-39
pubmed: 27016429
J Cereb Blood Flow Metab. 2015 Jul;35(7):1145-53
pubmed: 25712499
Proc Natl Acad Sci U S A. 2018 Feb 6;115(6):E1289-E1298
pubmed: 29358399
Neuroimage. 2006 Apr 1;30(2):436-43
pubmed: 16300968
Neurobiol Dis. 2019 Jun;126:124-136
pubmed: 30010004
Neurology. 2010 Dec 7;75(23):2071-8
pubmed: 21048201
Inf Process Med Imaging. 2009;21:239-51
pubmed: 19694267
Philos Trans R Soc Lond B Biol Sci. 2013 Dec 02;369(1633):20130140
pubmed: 24298142
CNS Neurosci Ther. 2018 Dec;24(12):1275-1285
pubmed: 30295998
Arch Neurol. 2008 Sep;65(9):1202-8
pubmed: 18779424
Acta Neuropathol. 2019 Feb;137(2):209-226
pubmed: 30413934
J Magn Reson Imaging. 1996 May-Jun;6(3):519-28
pubmed: 8724419
J Neurosci. 2012 Nov 14;32(46):16233-42
pubmed: 23152607
Acta Neuropathol. 2011 May;121(5):597-609
pubmed: 21311900
Hum Brain Mapp. 1999;8(4):272-84
pubmed: 10619420
J Vet Med Sci. 2014 Dec;76(12):1555-61
pubmed: 25649935
Ann Neurol. 2009 Apr;65(4):403-13
pubmed: 19296504
Neurology. 2010 Jan 19;74(3):201-9
pubmed: 20042704
Lancet Neurol. 2011 Sep;10(9):819-28
pubmed: 21775213
Brain. 2019 Aug 1;142(8):2483-2491
pubmed: 31199475
Dement Geriatr Cogn Dis Extra. 2018 May 16;8(2):199-206
pubmed: 29928288
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
IEEE Trans Med Imaging. 2007 Apr;26(4):518-29
pubmed: 17427739
J Biol Chem. 1996 Dec 20;271(51):32789-95
pubmed: 8955115
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Neurobiol Aging. 2000 Jan-Feb;21(1):57-62
pubmed: 10794849
JAMA Neurol. 2018 Aug 1;75(8):999-1007
pubmed: 29799981
Neurobiol Aging. 2015 Jan;36(1):27-32
pubmed: 25155654
EMBO J. 1992 Apr;11(4):1593-7
pubmed: 1563356
Neurology. 2004 Apr 13;62(7):1148-55
pubmed: 15079015
J Cogn Neurosci. 1993 Spring;5(2):162-76
pubmed: 23972151
Acta Neuropathol. 2006 Oct;112(4):389-404
pubmed: 16906426
J Cereb Blood Flow Metab. 2017 Jun;37(6):2208-2223
pubmed: 27486045
Alzheimers Dement. 2018 Aug;14(8):989-997
pubmed: 29626426
Cell Mol Life Sci. 2020 May;77(9):1721-1744
pubmed: 31667556
Nat Med. 2020 Mar;26(3):379-386
pubmed: 32123385
Alzheimers Dement. 2014 Nov;10(6):619-29
pubmed: 25304991
Neurology. 2018 Oct 9;91(15):e1402-e1412
pubmed: 30217936
Neurology. 2006 Dec 26;67(12):2192-8
pubmed: 17190943
Acta Neuropathol. 2017 Aug;134(2):171-186
pubmed: 28488154
Neurobiol Aging. 2012 Dec;33(12):2766-73
pubmed: 22410648
J Am Heart Assoc. 2015 Jun 23;4(6):001140
pubmed: 26104658
Neuroimage. 2006 Aug 1;32(1):180-94
pubmed: 16651008
JAMA Neurol. 2019 May 1;76(5):598-606
pubmed: 30830207
Brain Commun. 2020;2(1):fcz046
pubmed: 32051933
Nat Biotechnol. 2010 Jun;28(6):595-9
pubmed: 20495550
Alzheimers Dement. 2015 Dec;11(12):1510-1519
pubmed: 26079417
IEEE Trans Med Imaging. 2001 Jan;20(1):70-80
pubmed: 11293693
Resuscitation. 2013 Mar;84(3):351-6
pubmed: 22885094
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Alzheimers Dement (Amst). 2019 Jun 28;11:483-492
pubmed: 31334328
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Curr Opin Investig Drugs. 2009 Jul;10(7):624-37
pubmed: 19579168
J Cereb Blood Flow Metab. 2011 Mar;31(3):924-33
pubmed: 20877384
Acta Neuropathol Commun. 2018 Mar 2;6(1):22
pubmed: 29499767
Neuroimage. 2004;23 Suppl 1:S69-84
pubmed: 15501102
JAMA Neurol. 2017 Sep 1;74(9):1073-1080
pubmed: 28692710
Neuron. 2012 Feb 23;73(4):685-97
pubmed: 22365544
Neuroimage. 1999 Feb;9(2):195-207
pubmed: 9931269