The histopathological evaluation based on the indocyanine green fluorescence imaging of regional lymph node metastasis of splenic flexural colon cancer by near-infrared observation.
Colorectal cancer
Fluorescence
Indocyanine green
Lymph node metastasis
Near infrared
Journal
International journal of colorectal disease
ISSN: 1432-1262
Titre abrégé: Int J Colorectal Dis
Pays: Germany
ID NLM: 8607899
Informations de publication
Date de publication:
Apr 2021
Apr 2021
Historique:
accepted:
10
11
2020
pubmed:
21
11
2020
medline:
24
6
2021
entrez:
20
11
2020
Statut:
ppublish
Résumé
The purpose of this study was to investigate the relationship between the fluorescence on indocyanine green fluorescent imaging (ICG-FI) and the histopathological findings of regional lymph node (LN) metastasis of splenic flexural colon cancer. From July 2013 to December 2018, consecutive patients with splenic flexural colon cancer with a preoperative diagnosis of N0 who underwent laparoscopic surgery were enrolled. The distribution of cancer sites in metastatic LNs (completely/not completely occupied by metastatic foci) was evaluated with hematoxylin and eosin-stained preparations. We compared the relationship between the distribution of cancer site and fluorescence of paraffin block in metastatic LNs. Seventy-two patients were enrolled, of whom 13 (18.1%) had metastatic LNs. A total of 25 metastatic LNs were evaluated. The median short axis of the occupied LNs was 4.5 mm, which was significantly larger than that of the non-occupied LNs (3.0 mm; p = 0.036). In the near-infrared observation of the paraffin block, the completely occupied LNs showed no fluorescence, regardless of the LN size, but 8 of 10 non-occupied LNs showed fluorescence (p < 0.001). Even the non-occupied LNs that showed fluorescence, the cancer site did not show fluorescence. The occupied LNs showed no fluorescence, but 80% of the non-occupied LNs showed fluorescence. Even in non-occupied LNs that showed fluorescence, the cancer site did not show fluorescence. This demonstrated LN dissection should not be omitted, even if no fluorescence is noted on intraoperative ICG-FI.
Identifiants
pubmed: 33215238
doi: 10.1007/s00384-020-03798-2
pii: 10.1007/s00384-020-03798-2
doi:
Substances chimiques
Indocyanine Green
IX6J1063HV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
717-723Références
Holm C, Tegeler J, Mayr M et al (2002) Monitoring free flaps using laser-induced fluorescence of indocyanine green: a preliminary experience. Micorsurgery 22:278–287
doi: 10.1002/micr.10052
Hutteman M, van der Vorst JR, Mieog JS et al (2011) Near-infrared fluorescence imaging in patients undergoing pancreaticoduodenectomy. Eur Surg Res 47:90–97
doi: 10.1159/000329411
Rodriguez-Hernandez A, Lawton MT (2012) Flash fluorescence with indocyanine green videoangiography to identify the recipient artery for bypass with distal middle cerebral artery aneurysms: operative technique. Neurosurgery 70:209–220
pubmed: 21841520
Shimada Y, Okumura T, Nagata T et al (2011) Usefulness of blood supply visualization by indocyanine green fluorescence for reconstruction during esophagectomy. Esophagus 8:259–266
doi: 10.1007/s10388-011-0291-7
Still J, Law E, Dawson J, Island T, Holtz J (1999) Evaluation of the circulation of reconstructive flaps using laser-induced fluorescence of indocyanine green. Ann Plast Surg 42:266–274
doi: 10.1097/00000637-199903000-00007
Waseda K, Ako J, Hasegawa T et al (2009) Intraoperative fluorescence imaging system for on-site assessment of off-pump coronary artery bypass graft. JACC 2:604–612
pubmed: 19442948
Vasey CE, Rajaratnam S, O'Grady G, Hulme-Moir M (2018) Lymphatic drainage of the splenic flexure defined by intraoperative scintigraphic mapping. Dis Colon Rectum 61:441–446
doi: 10.1097/DCR.0000000000000986
Watanabe J, Ota M, Suwa Y, Ishibe A, Masui H, Nagahori K (2016) Real-time indocyanine green fluorescence imaging-guided complete mesocolic excision in laparoscopic flexural colon cancer surgery. Dis Colon Rectum 59:701–705
doi: 10.1097/DCR.0000000000000608
Watanabe J, Ota M, Suwa Y et al (2017) Evaluation of lymph flow patterns in splenic flexural colon cancers using laparoscopic real-time indocyanine green fluorescence Imaging. Int J Color Dis 32:201–207
doi: 10.1007/s00384-016-2669-4
Watanabe J, Ishibe A, Suwa Y et al (2018) Real-time indocyanine green fluorescence imaging-guided laparoscopic right hemicolectomy in hepatic flexural colon cancer. Dis Colon Rectum 61:1333–1334
doi: 10.1097/DCR.0000000000001151
Jafari MD, Wexner SD, Martz JE et al (2015) Perfusion assessment in laparoscopic left-sided/anterior resection (PILLAR II): a multi-institutional study. J Am Coll Surg 220:82–92
doi: 10.1016/j.jamcollsurg.2014.09.015
Ris F, Liot E, Buchs NC et al (2018) Multicentre phase II trial of near-infrared imaging in elective colorectal surgery. Br J Surg 05:1359–1367
doi: 10.1002/bjs.10844
Watanabe J, Ishibe A, Suwa Y et al (2020) Indocyanine green fluorescence imaging to reduce the risk of anastomotic leakage in laparoscopic low anterior resection for rectal cancer: a propensity score-matched cohort study. Surg Endosc 34:202–208
doi: 10.1007/s00464-019-06751-9
Nardi PD, Elmore U, Maggi G et al (2020) Intraoperative angiography with indocyanine green to assess anastomosis perfusion in patients undergoing laparoscopic colorectal resection: results of a multicenter randomized controlled trial. Surg Endosc 34:53–60
doi: 10.1007/s00464-019-06730-0
Jafari MD, Lee KH, Halabi WJ et al (2013) The use of indocyanine green fluorescence to assess anastomotic perfusion during robotic assisted laparoscopic rectal surgery. Surg Endosc 278:3003–3008
doi: 10.1007/s00464-013-2832-8
Kudszus S, Roesel C, Schachtrupp A, Höer JJ (2010) Intraoperative laser fluorescence angiography in colorectal surgery: a noninvasive analysis to reduce the rate of anastomotic leakage. Langenbeck's Arch Surg 395:1025–1030
doi: 10.1007/s00423-010-0699-x
Sherwinter DA, Gallagher J, Donkar T (2013) Intra-operative transanal near infrared imaging of colorectal anastomotic perfusion: a feasibility study. Color Dis 15:91–96
doi: 10.1111/j.1463-1318.2012.03101.x
Cahill RA, Anderson M, Wang LM, Lindsey I, Cunningham C, Mortensen NJ (2012) Near-infrared (NIR) Laparoscopy for intraoperative lymphatic road-mapping and sentinel node identification during definitive surgical resection of early-stage colorectal neoplasia. Surg Endosc 26:197–204
doi: 10.1007/s00464-011-1854-3
Nishigori N, Koyama F, Nakagawa T et al (2016) Visualization of lymph/blood flow in laparoscopic colorectal cancer surgery by ICG fluorescence imaging (Lap-IGFI). Ann Surg Oncol 23(supple2):266–274
doi: 10.1245/s10434-015-4509-0
Cahill RA, Leroy J, Marescaux J (2008) Could lymphatic mapping and sentinel node biopsy provide oncological providence for local resectional techniques for colon cancer? A review of the literature. BMC Surg 8:17
doi: 10.1186/1471-2482-8-17
Yanagita S, Natsugoe S, Uenosono Y et al (2008) Detection of micrometastases in sentinel node navigation surgery for gastric cancer. Surg Oncol 17:203–210
doi: 10.1016/j.suronc.2008.04.008
Boogerd LSF, Hoogstins CES, Schaap DP et al (2018) Safety and effectiveness of SGM-101, a fluorescent antibody targeting carcinoembryonic antigen, for intraoperative detection of colorectal cancer: a dose-escalation pilot study. Lancet Gastroenterol Hepatol 3:181–191
doi: 10.1016/S2468-1253(17)30395-3