The impact of demographic, clinical, genetic, and imaging variables on tau PET status.


Journal

European journal of nuclear medicine and molecular imaging
ISSN: 1619-7089
Titre abrégé: Eur J Nucl Med Mol Imaging
Pays: Germany
ID NLM: 101140988

Informations de publication

Date de publication:
07 2021
Historique:
received: 24 09 2020
accepted: 27 10 2020
pubmed: 21 11 2020
medline: 29 6 2021
entrez: 20 11 2020
Statut: ppublish

Résumé

A substantial proportion of amyloid-β (Aβ)+ patients with clinically diagnosed Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI) are tau PET-negative, while some clinically diagnosed non-AD neurodegenerative disorder (non-AD) patients or cognitively unimpaired (CU) subjects are tau PET-positive. We investigated which demographic, clinical, genetic, and imaging variables contributed to tau PET status. We included 2338 participants (430 Aβ+ AD dementia, 381 Aβ+ MCI, 370 non-AD, and 1157 CU) who underwent [ Tau PET positivity in the temporal meta-ROI was 88.6% for AD dementia, 46.5% for MCI, 9.5% for non-AD, and 6.1% for CU. Among Aβ+ participants with AD dementia and MCI, lower age, MMSE score, and AD-signature cortical thickness showed the strongest associations with tau PET positivity. In non-AD and CU participants, presence of Aβ was the strongest predictor of a positive tau PET scan. We identified several demographic, clinical, and neurobiological factors that are important to explain the variance in tau PET retention observed across the AD pathological continuum, non-AD neurodegenerative disorders, and cognitively unimpaired persons.

Identifiants

pubmed: 33215319
doi: 10.1007/s00259-020-05099-w
pii: 10.1007/s00259-020-05099-w
pmc: PMC8131404
mid: NIHMS1662667
doi:

Substances chimiques

Amyloid beta-Peptides 0
tau Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2245-2258

Subventions

Organisme : EPA
ID : EP-W-17-011
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG063911
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG019724
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS050915
Pays : United States
Organisme : NIA NIH HHS
ID : K99 AG065501
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG038791
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062422
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG045611
Pays : United States
Organisme : NIDCD NIH HHS
ID : K24 DC015544
Pays : United States

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Auteurs

Rik Ossenkoppele (R)

Clinical Memory Research Unit, Lund University, Lund, Sweden. r.ossenkoppele@amsterdamumc.nl.
Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, VU University Medical Center, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. r.ossenkoppele@amsterdamumc.nl.

Antoine Leuzy (A)

Clinical Memory Research Unit, Lund University, Lund, Sweden.

Hanna Cho (H)

Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Carole H Sudre (CH)

School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK.
Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.
Centre for Medical Image Computing, Department of Medical Physics, University College London, London, UK.

Olof Strandberg (O)

Clinical Memory Research Unit, Lund University, Lund, Sweden.

Ruben Smith (R)

Clinical Memory Research Unit, Lund University, Lund, Sweden.

Sebastian Palmqvist (S)

Clinical Memory Research Unit, Lund University, Lund, Sweden.

Niklas Mattsson-Carlgren (N)

Clinical Memory Research Unit, Lund University, Lund, Sweden.
Department of Neurology, Skåne University Hospital, Lund, Sweden.
Wallenberg Centre for Molecular Medicine, Lund University, Lund, Sweden.

Tomas Olsson (T)

Department of Radiation Physics, Skåne University Hospital, Lund, Sweden.

Jonas Jögi (J)

Department of Clinical Physiology and Nuclear Medicine, Skåne University Hospital, Lund, Sweden.

Erik Stormrud (E)

Clinical Memory Research Unit, Lund University, Lund, Sweden.
Memory Clinic, Skåne University Hospital, Malmö, Sweden.

Young Hoon Ryu (YH)

Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Jae Yong Choi (JY)

Department of Nuclear Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Division of applied RI, Korea Institute Radiological and Medical Sciences, Seoul, South Korea.

Adam L Boxer (AL)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

Maria L Gorno-Tempini (ML)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

Bruce L Miller (BL)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

David Soleimani-Meigooni (D)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

Leonardo Iaccarino (L)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

Renaud La Joie (R)

Department of Neurology, Memory and Aging Center, University of California San Francisco, San Francisco, USA.

Edilio Borroni (E)

F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Gregory Klein (G)

F. Hoffmann-La Roche Ltd, Basel, Switzerland.

Michael J Pontecorvo (MJ)

Avid Radiopharmaceuticals, Philadelphia, PA, USA.

Michael D Devous (MD)

Avid Radiopharmaceuticals, Philadelphia, PA, USA.

Sylvia Villeneuve (S)

Departments of Psychiatry and Neurology & Neurosurgery, Douglas Mental Health University Institute, McGill University, Montreal, Quebec, Canada.

Chul Hyoung Lyoo (CH)

Department of Neurology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Gil D Rabinovici (GD)

F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, USA.
Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

Oskar Hansson (O)

Clinical Memory Research Unit, Lund University, Lund, Sweden. oskar.hansson@med.lu.se.
Memory Clinic, Skåne University Hospital, Malmö, Sweden. oskar.hansson@med.lu.se.

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