The Constitutive Proteome of Human Aqueous Humor and Race Specific Alterations.
aqueous humor
mass spectrometry
proteomics
Journal
Proteomes
ISSN: 2227-7382
Titre abrégé: Proteomes
Pays: Switzerland
ID NLM: 101621966
Informations de publication
Date de publication:
18 Nov 2020
18 Nov 2020
Historique:
received:
15
10
2020
revised:
11
11
2020
accepted:
13
11
2020
entrez:
21
11
2020
pubmed:
22
11
2020
medline:
22
11
2020
Statut:
epublish
Résumé
Aqueous humor (AH) is the fluid in the anterior and posterior chambers of the eye that contains proteins regulating ocular homeostasis. Analysis of aqueous humor proteome is challenging, mainly due to low sample volume and protein concentration. In this study, by utilizing state of the art technology, we performed Liquid-Chromatography Mass spectrometry (LC-MS/MS) analysis of 88 aqueous humor samples from subjects undergoing cataract surgery. A total of 2263 unique proteins were identified, which were sub-divided into four categories that were based on their detection in the number of samples: High (
Identifiants
pubmed: 33217969
pii: proteomes8040034
doi: 10.3390/proteomes8040034
pmc: PMC7709111
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NEI NIH HHS
ID : R01 EY029728
Pays : United States
Organisme : NEI NIH HHS
ID : P30 EY031631
Pays : United States
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