Evaluation of the Role of Circulating Tumor Cells and Microsatellite Instability Status in Predicting Outcome of Advanced CRC Patients.
CEACAM5
CTCs
colorectal cancer
metastatic
microsatellite instability
Journal
Journal of personalized medicine
ISSN: 2075-4426
Titre abrégé: J Pers Med
Pays: Switzerland
ID NLM: 101602269
Informations de publication
Date de publication:
18 Nov 2020
18 Nov 2020
Historique:
received:
06
10
2020
revised:
29
10
2020
accepted:
16
11
2020
entrez:
21
11
2020
pubmed:
22
11
2020
medline:
22
11
2020
Statut:
epublish
Résumé
Colorectal cancer (CRC) remains one of the leading causes of cancer-related death due to its high metastatic potential. This study aimed to investigate the detection and heterogeneity of circulating tumor cells (CTCs) and the microsatellite instability (MSI) status in advanced CRC patients prior to any systemic front-line treatment. Peripheral whole blood was obtained from 198 patients. CTCs were detected using double immunofluorescence and a real time-polymerase chain reaction assay; whereas MSI status was evaluated using fragment analysis. Median age of the patients was 66 years, 63.1% were males, 65.2% had a colon/sigmoid tumor location and 90.4% had a good performance status (PS). MSI-High status was detected in 4.9% of the patients; 33.3%, 56.1% and 8.6% patients had at least one detectable CEACAM5
Identifiants
pubmed: 33217974
pii: jpm10040235
doi: 10.3390/jpm10040235
pmc: PMC7712177
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Gastrointestinal Cancer Study Group
ID : N/A
Organisme : Hellenic Society of Medical Oncology
ID : N/A
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