Evaluation of Urinary Big Endothelin-1 in Feline Spontaneous CKD.
chronic renal failure
hypertension
proteinuria
urine
Journal
Animals : an open access journal from MDPI
ISSN: 2076-2615
Titre abrégé: Animals (Basel)
Pays: Switzerland
ID NLM: 101635614
Informations de publication
Date de publication:
18 Nov 2020
18 Nov 2020
Historique:
received:
08
10
2020
revised:
09
11
2020
accepted:
16
11
2020
entrez:
21
11
2020
pubmed:
22
11
2020
medline:
22
11
2020
Statut:
epublish
Résumé
The endothelin-1 (ET-1) system has been implicated in the development and progression of chronic kidney disease (CKD). No information on big ET-1 in feline urine is available. The purpose of this study was to evaluate if urinary big endothelin-1 (bigET-1) is associated with feline CKD. Sixty urine samples were prospectively collected from 13 healthy cats at risk of developing CKD and 22 cats with CKD of different International Renal Interest Society (IRIS) stages (1-4). Urinary bigET-1 was measured using a commercially available ELISA. BigET-1 normalized to urine creatinine (bigET-1:UC) was compared amongst stages and substages, as proposed by IRIS, and correlated with serum creatinine concentration, proteinuria and blood pressure. BigET-1:UC at the time of inclusion was compared between cats that remained stable and cats that progressed after 12 months. BigET-1:UC was significantly higher (
Identifiants
pubmed: 33217985
pii: ani10112144
doi: 10.3390/ani10112144
pmc: PMC7698635
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Winn Feline Foundation
ID : WZ14-009
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