E3 Ubiquitin Ligase APC/C
Anaphase-Promoting Complex-Cyclosome
/ metabolism
Antigens, CD
/ genetics
Cdh1 Proteins
/ genetics
Gene Expression Regulation, Neoplastic
HEK293 Cells
Humans
Hydrolases
/ genetics
Liver Neoplasms
/ genetics
Proteasome Endopeptidase Complex
/ metabolism
Protein Stability
Proteolysis
Ubiquitin-Protein Ligases
/ genetics
Ubiquitination
CRISPR/Cas9 knockout
in silico analysis
liver cancer
post-translational modifications
ubiquitin-proteasome system
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
18 Nov 2020
18 Nov 2020
Historique:
received:
01
10
2020
revised:
13
11
2020
accepted:
16
11
2020
entrez:
21
11
2020
pubmed:
22
11
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Fumarylacetoacetate hydrolase (FAH) is the last enzyme in the degradation pathway of the amino acids tyrosine and phenylalanine in mammals that catalyzes the hydrolysis of 4-fumarylacetoacetate into acetoacetate and fumarate. Mutations of the
Identifiants
pubmed: 33218190
pii: ijms21228719
doi: 10.3390/ijms21228719
pmc: PMC7699203
pii:
doi:
Substances chimiques
Antigens, CD
0
Cdh1 Proteins
0
FZR1 protein, human
0
Anaphase-Promoting Complex-Cyclosome
EC 2.3.2.27
Ubiquitin-Protein Ligases
EC 2.3.2.27
Hydrolases
EC 3.-
Proteasome Endopeptidase Complex
EC 3.4.25.1
ATP dependent 26S protease
EC 3.4.99.-
fumarylacetoacetase
EC 3.7.1.2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : National Research Foundation of Korea
ID : 2018M3A9H3022412
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