Ethosuximide induced macroglossia and oropharyngeal edema.
Antiepileptic drugs
Drug-induced macroglossia
Ethosuximide
Macroglossia
Journal
International journal of pediatric otorhinolaryngology
ISSN: 1872-8464
Titre abrégé: Int J Pediatr Otorhinolaryngol
Pays: Ireland
ID NLM: 8003603
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
23
07
2020
revised:
10
11
2020
accepted:
11
11
2020
pubmed:
22
11
2020
medline:
24
6
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
Acute macroglossia and laryngeal edema are rare adverse side effects that can cause life-threatening airway obstruction. We report a case of acute macroglossia that began after initiation of ethosuximide in a 15-year-old female with severe medically refractory epilepsy. Macroglossia worsened over the next two weeks of ethosuximide administration, preventing extubation. Macroglossia and laryngeal edema improved upon ethosuximide wean, and completely resolved after discontinuation. The patient was extubated successfully, with precautionary nasal trumpet placement and dexamethasone administration prior to extubation. In medically complex patients on multiple pharmacologic agents, anti-epileptic drugs should be suspected as a possible cause of acute macroglossia.
Identifiants
pubmed: 33218689
pii: S0165-5876(20)30641-8
doi: 10.1016/j.ijporl.2020.110498
pii:
doi:
Substances chimiques
Ethosuximide
5SEH9X1D1D
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110498Informations de copyright
Copyright © 2020. Published by Elsevier B.V.