Circulating biomarkers of nitric oxide bioactivity and impaired muscle vasoreactivity to exercise in adults with uncomplicated type 1 diabetes.
Adolescent
Adult
Arginine
/ metabolism
Case-Control Studies
Diabetes Mellitus, Type 1
/ metabolism
Endothelium, Vascular
/ physiopathology
Exercise
/ physiology
Female
Humans
Lipid Peroxidation
Male
Microvessels
/ physiopathology
Muscle, Skeletal
/ blood supply
Nitric Oxide
/ metabolism
Oxidative Stress
Oxygen Consumption
/ physiology
Spectroscopy, Near-Infrared
Uric Acid
/ metabolism
Vasodilation
/ physiology
Young Adult
Aerobic fitness
Antioxidant defences
L-arginine
Nitric oxide
Oxidative stress
Physical exercise
Skeletal muscle
Type 1 diabetes
Urate
Vasoreactivity
Journal
Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777
Informations de publication
Date de publication:
02 2021
02 2021
Historique:
received:
28
07
2020
accepted:
29
09
2020
pubmed:
22
11
2020
medline:
21
1
2022
entrez:
21
11
2020
Statut:
ppublish
Résumé
Early compromised endothelial function challenges the ability of individuals with type 1 diabetes to perform normal physical exercise. The exact mechanisms underlying this vascular limitation remain unknown, but may involve either formation or metabolism of nitric oxide (NO), a major vasodilator, whose activity is known to be compromised by oxidative stress. Muscle microvascular reactivity (near-infrared spectroscopy) to an incremental exhaustive bout of exercise was assessed in 22 adults with uncomplicated type 1 diabetes (HbA Maximal oxygen uptake was impaired in individuals with type 1 diabetes compared with in healthy participants (35.6 ± 7.7 vs 39.6 ± 6.8 ml min clinicaltrials.gov NCT02051504.
Identifiants
pubmed: 33219433
doi: 10.1007/s00125-020-05329-8
pii: 10.1007/s00125-020-05329-8
doi:
Substances chimiques
Uric Acid
268B43MJ25
Nitric Oxide
31C4KY9ESH
Arginine
94ZLA3W45F
Banques de données
ClinicalTrials.gov
['NCT02051504']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
325-338Subventions
Organisme : North of France Region
ID : Programme Emergent, 2013
Organisme : interregional hospital program of clinical research
ID : 2010
Organisme : Société Francophone du Diabète
ID : ALFEDIAM-Roche Diagnostics 2009
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