Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids.

Adult Amino Acids, Branched-Chain Bariatric Surgery Humans Male Middle Aged Non-alcoholic Fatty Liver Disease Phosphatidylcholines
DNA methylation LDL cholesterol NAFLD NASH aromatic amino acids epigenetics non-targeted metabolomics tryptophan

Journal

Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857

Informations de publication

Date de publication:
04 2021
Historique:
revised: 04 11 2020
received: 17 06 2020
accepted: 18 11 2020
pubmed: 22 11 2020
medline: 22 6 2021
entrez: 21 11 2020
Statut: ppublish

Résumé

Non-alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non-targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associates with NAFLD would differ in its association with NAFLD-related metabolic risk factors. A total of 233 subjects (mean ± SD: 48.3 ± 9.3 years old; BMI: 43.1 ± 5.4 kg/m We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver.

Sections du résumé

BACKGROUND & AIMS
Non-alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non-targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associates with NAFLD would differ in its association with NAFLD-related metabolic risk factors.
METHODS & RESULTS
A total of 233 subjects (mean ± SD: 48.3 ± 9.3 years old; BMI: 43.1 ± 5.4 kg/m
CONCLUSIONS
We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver.

Identifiants

DOI: 10.1111/liv.14743 PMID: 33219609 PMC: PMC8048463
pubmed: 33219609
doi: 10.1111/liv.14743
pmc: PMC8048463
doi:

Substances chimiques

Amino Acids, Branched-Chain 0
Phosphatidylcholines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

754-763

Subventions

Organisme : NHLBI NIH HHS
ID : P01 HL028481
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK105561
Pays : United States

Informations de copyright

© 2020 The Authors. Liver International published by John Wiley & Sons Ltd.

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Auteurs

Vanessa D de Mello (VD)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
ORCID: 0000-0003-3414-6983

Ratika Sehgal (R)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Ville Männistö (V)

Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.

Anton Klåvus (A)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Emma Nilsson (E)

Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

Alexander Perfilyev (A)

Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

Dorota Kaminska (D)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.

Zong Miao (Z)

Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA.

Päivi Pajukanta (P)

Department of Human Genetics, David Geffen School of Medicine at University of California Los Angeles (UCLA), Los Angeles, CA, USA.
Institute for Precision Health, School of Medicine, UCLA, Los Angeles, CA, USA.

Charlotte Ling (C)

Epigenetics and Diabetes Unit, Department of Clinical Sciences, Lund University Diabetes Centre, Malmö, Sweden.

Kati Hanhineva (K)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Biochemistry, Food Chemistry and Food Development Unit, University of Turku, Turku, Finland.

Jussi Pihlajamäki (J)

Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Medicine, Endocrinology and Clinical Nutrition, Kuopio University Hospital, Kuopio, Finland.
ORCID: 0000-0002-6241-6859

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés à chaine ramifiée › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Procédures de chirurgie opératoire › Chirurgie bariatrique › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du foie › Stéatose hépatique › Stéatose hépatique non alcoolique › Serum aromatic and branched-chain amino acids...
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Glycérophospholipides › Phosphatidylcholines › Serum aromatic and branched-chain amino acids...