Engineering spatiotemporal organization and dynamics in synthetic cells.
artificial cells
in vitro reconstitution
protein compartment
synthetic cell
Journal
Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology
ISSN: 1939-0041
Titre abrégé: Wiley Interdiscip Rev Nanomed Nanobiotechnol
Pays: United States
ID NLM: 101508311
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
13
10
2020
received:
27
04
2020
accepted:
30
10
2020
pubmed:
22
11
2020
medline:
5
11
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
Constructing synthetic cells has recently become an appealing area of research. Decades of research in biochemistry and cell biology have amassed detailed part lists of components involved in various cellular processes. Nevertheless, recreating any cellular process in vitro in cell-sized compartments remains ambitious and challenging. Two broad features or principles are key to the development of synthetic cells-compartmentalization and self-organization/spatiotemporal dynamics. In this review article, we discuss the current state of the art and research trends in the engineering of synthetic cell membranes, development of internal compartmentalization, reconstitution of self-organizing dynamics, and integration of activities across scales of space and time. We also identify some research areas that could play a major role in advancing the impact and utility of engineered synthetic cells. This article is categorized under: Biology-Inspired Nanomaterials > Lipid-Based Structures Biology-Inspired Nanomaterials > Protein and Virus-Based Structures.
Identifiants
pubmed: 33219745
doi: 10.1002/wnan.1685
pmc: PMC8162676
mid: NIHMS1703061
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1685Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM119688
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM133325
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals LLC.
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