Updating the International IgA Nephropathy Prediction Tool for use in children.
IgA nephropathy
children
disease progression
estimated glomerular filtration rate trajectory
pediatrics
prediction
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
06 2021
06 2021
Historique:
received:
05
08
2020
revised:
22
10
2020
accepted:
30
10
2020
pubmed:
22
11
2020
medline:
25
6
2021
entrez:
21
11
2020
Statut:
ppublish
Résumé
Although IgA nephropathy (IgAN) is a common cause of glomerulonephritis in children, the absence of a method to predict disease progression limits personalized risk-based treatment decisions. The adult International IgAN Prediction Tool comprises two validated Cox survival models that predict a 50% decline in estimated glomerular filtration rate (eGFR) or end stage kidney disease (ESKD) using clinical risk factors and Oxford MEST histology scores. Here, we updated the Prediction Tool for use in children using a multiethnic international cohort of 1,060 children with IgAN followed into adulthood. The updated pediatric Prediction Tool had better model fit than the original adult tool with lower Akaike Information Criterion, higher R
Identifiants
pubmed: 33220356
pii: S0085-2538(20)31385-5
doi: 10.1016/j.kint.2020.10.033
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1439-1450Subventions
Organisme : CIHR
ID : PCG-155557
Pays : Canada
Investigateurs
Caihong Zeng
(C)
Biage Su
(B)
Xuhui Zhong
(X)
Koichi Nakanishi
(K)
Yihui Zhai
(Y)
Maki Urushihara
(M)
Motoshi Hattori
(M)
Francesca Diomedi Camassei
(FD)
Antonella Barreca
(A)
Thomas Robert
(T)
Larisa Prikhodina
(L)
Ulla Berg
(U)
Rezan Topaloglu
(R)
Malgorzata Mizerska-Wasiak
(M)
Aikaterini Papagianni
(A)
Shubha S Bellur
(SS)
Ian Roberts
(I)
Informations de copyright
Copyright © 2020 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.