Magnesium and inflammation: Advances and perspectives.

Animals Cation Transport Proteins / metabolism Endothelial Cells / metabolism Homeostasis / physiology Humans Inflammation / metabolism Magnesium / metabolism Magnesium Deficiency / metabolism
COVID-19 Inflammation MagT1 Magnesium Non-communicable diseases TRPM7

Journal

Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332

Informations de publication

Date de publication:
07 2021
Historique:
received: 04 09 2020
revised: 06 11 2020
accepted: 06 11 2020
pubmed: 23 11 2020
medline: 10 7 2021
entrez: 22 11 2020
Statut: ppublish

Résumé

Magnesium is an essential element of life, involved in the regulation of metabolism and homeostasis of all the tissues. It also regulates immunological functions, acting on the cells of innate and adaptive immune systems. Magnesium deficiency primes phagocytes, enhances granulocyte oxidative burst, activates endothelial cells and increases the levels of cytokines, thus promoting inflammation. Consequently, a low magnesium status, which is often underdiagnosed, potentiates the reactivity to various immune challenges and is implicated in the pathophysiology of many common chronic diseases. Here we summarize recent advances supporting the link between magnesium deficiency, inflammatory responses and diseases, and offer new hints towards a better understanding of the underlying mechanisms.

Identifiants

DOI: 10.1016/j.semcdb.2020.11.002 PMID: 33221129
pubmed: 33221129
pii: S1084-9521(20)30171-3
doi: 10.1016/j.semcdb.2020.11.002
pii:
doi:

Substances chimiques

Cation Transport Proteins 0
Magnesium I38ZP9992A

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

37-44

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Jeanette A Maier (JA)

Università di Milano, Department Biomedical and Clinical Sciences L. Sacco, Via GB Grassi 74, I20157 Milano, Italy. Electronic address: jeanette.maier@unimi.it.

Sara Castiglioni (S)

Università di Milano, Department Biomedical and Clinical Sciences L. Sacco, Via GB Grassi 74, I20157 Milano, Italy.

Laura Locatelli (L)

Università di Milano, Department Biomedical and Clinical Sciences L. Sacco, Via GB Grassi 74, I20157 Milano, Italy.

Monica Zocchi (M)

Università di Milano, Department Biomedical and Clinical Sciences L. Sacco, Via GB Grassi 74, I20157 Milano, Italy.

André Mazur (A)

Université Clermont Auvergne, INRAE, Unité de Nutrition Humaine, UNH, Clermont-Ferrand, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Pompes ioniques › Transporteurs de cations › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux légers › Magnésium › Magnesium and inflammation: Advances and perspectives.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Maladies de carence › Magnésium, carence › Magnesium and inflammation: Advances and perspectives.