Transcriptome profiling in adult attention-deficit hyperactivity disorder.
Attention-deficit/hyperactivity disorder (ADHD)
Gene-expression signatures
Transcriptomic assays
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
01
04
2020
revised:
04
10
2020
accepted:
02
11
2020
pubmed:
23
11
2020
medline:
24
9
2021
entrez:
22
11
2020
Statut:
ppublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an estimated heritability of around 70%. Although the largest genome-wide association study (GWAS) meta-analysis on ADHD identified independent loci conferring risk to the disorder, the molecular mechanisms underlying the genetic basis of the disorder remain to be elucidated. To explore ADHD biology, we ran a two-step transcriptome profiling in peripheral blood mononuclear cells (PBMCs) of 143 ADHD subjects and 169 healthy controls. Through this exploratory study we found eight differentially expressed genes in ADHD. These results highlight promising candidate genes and gene pathways for ADHD and support the use of peripheral tissues to assess gene expression signatures for ADHD.
Identifiants
pubmed: 33221139
pii: S0924-977X(20)30937-8
doi: 10.1016/j.euroneuro.2020.11.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
160-166Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.