NIRS-IVUS for Differentiating Coronary Plaque Rupture, Erosion, and Calcified Nodule in Acute Myocardial Infarction.
calcified nodule
intravascular ultrasound
near-infrared spectroscopy
optical coherence tomography
plaque erosion
plaque rupture
Journal
JACC. Cardiovascular imaging
ISSN: 1876-7591
Titre abrégé: JACC Cardiovasc Imaging
Pays: United States
ID NLM: 101467978
Informations de publication
Date de publication:
07 2021
07 2021
Historique:
received:
17
03
2020
revised:
27
07
2020
accepted:
06
08
2020
pubmed:
23
11
2020
medline:
9
10
2021
entrez:
22
11
2020
Statut:
ppublish
Résumé
This study sought to investigate the ability of combined near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) to differentiate plaque rupture (PR), plaque erosion (PE), or calcified nodule (CN) in acute myocardial infarction (AMI). Most acute coronary syndromes occur from coronary thrombosis based on PR, PE, or CN. In vivo differentiation among PR, PE, and CN is a major challenge for intravascular imaging. The study enrolled 244 patients with AMI who had a de novo culprit lesion in a native coronary artery. The culprit lesions were assessed by both NIRS-IVUS and optical coherence tomography (OCT). Maximum lipid core burden index in 4 mm (maxLCBI In the development cohort, IVUS-detected plaque cavity showed a high specificity (100%) and intermediate sensitivity (62%) for identifying OCT-PR. IVUS-detected convex calcium showed a high sensitivity (93%) and specificity (100%) for identifying OCT-CN. NIRS-measured maxLCBI By evaluating plaque cavity, convex calcium, and maxLCBI
Sections du résumé
OBJECTIVES
This study sought to investigate the ability of combined near-infrared spectroscopy and intravascular ultrasound (NIRS-IVUS) to differentiate plaque rupture (PR), plaque erosion (PE), or calcified nodule (CN) in acute myocardial infarction (AMI).
BACKGROUND
Most acute coronary syndromes occur from coronary thrombosis based on PR, PE, or CN. In vivo differentiation among PR, PE, and CN is a major challenge for intravascular imaging.
METHODS
The study enrolled 244 patients with AMI who had a de novo culprit lesion in a native coronary artery. The culprit lesions were assessed by both NIRS-IVUS and optical coherence tomography (OCT). Maximum lipid core burden index in 4 mm (maxLCBI
RESULTS
In the development cohort, IVUS-detected plaque cavity showed a high specificity (100%) and intermediate sensitivity (62%) for identifying OCT-PR. IVUS-detected convex calcium showed a high sensitivity (93%) and specificity (100%) for identifying OCT-CN. NIRS-measured maxLCBI
CONCLUSIONS
By evaluating plaque cavity, convex calcium, and maxLCBI
Identifiants
pubmed: 33221211
pii: S1936-878X(20)30827-5
doi: 10.1016/j.jcmg.2020.08.030
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1440-1450Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2021 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Funding Support And Author Disclosures Dr. Madder has received speaker honoraria and research support from Infraredx; and has served on the advisory board of SpectraWave. Dr. Akasaka has received lecture fees from Abbott Vascular, Terumo, and Nipro; and has received research grants from Abbott Vascular, Terumo, and Nipro. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose.