Animals Autoradiography Fluorides Fluorine Radioisotopes Ligands Positron-Emission Tomography Radiopharmaceuticals
HSP(90) PET cancer fluorine-18

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Feb 2021
Historique:
received: 04 08 2020
revised: 03 11 2020
accepted: 11 11 2020
pubmed: 23 11 2020
medline: 22 6 2021
entrez: 22 11 2020
Statut: ppublish

Résumé

With the ambition of improving the management of pancreatic neuroendocrine tumors (P-NETs), we developed and preliminary validated a novel fluorine-18 labelled HSP A precursor containing methoxymethyl ethers protecting groups and a tosyl as leaving group was synthesized. The target compound was labeled with nucleophilic The precursor was successfully synthesized and utilized in the Despite the unfavorable in vivo properties of the tracer, the promising results from in vitro autoradiography experiments in frozen sections of P-NETs from surgical resection encourage us to continue the project aiming the improvement of in vivo properties of the tracer.

Identifiants

DOI: 10.1016/j.ejps.2020.105647 PMID: 33221456
pubmed: 33221456
pii: S0928-0987(20)30435-8
doi: 10.1016/j.ejps.2020.105647
pii:
doi:

Substances chimiques

Fluorine Radioisotopes 0
Ligands 0
Radiopharmaceuticals 0
Fluorides Q80VPU408O

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

105647

Informations de copyright

Copyright © 2020. Published by Elsevier B.V.

Auteurs

P Nordeman (P)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden. Electronic address: patrik.nordeman@akademiska.se.

Z P Jayendra (ZP)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

E Briard (E)

Global Discovery Chemistry, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Klybeckstrasse 141, 4057 Basel, Switzerland.

S C Li (SC)

Department of Medical Sciences, Uppsala University, SE-751 05 Uppsala, Sweden.

M Larhed (M)

Department of Medicinal Chemistry, Science for Life Laboratory, BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.

G Antoni (G)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

S Estrada (S)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

R K Selvaraju (RK)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

O Åberg (O)

Department of Medicinal Chemistry, BMC, Uppsala University, Box 574, SE-751 23 Uppsala, Sweden.

M R Jensen (MR)

Oncology, Novartis Institutes for Biomedical Research, Novartis Pharma AG, Klybeckstrasse 141, 4057 Basel, Switzerland.

P Stålberg (P)

Departments of Surgical Sciences, Uppsala University, SE-751 85 Uppsala, Sweden.

B Skogseid (B)

Department of Medical Sciences, Uppsala University, SE-751 05 Uppsala, Sweden.

A Monazzam (A)

Department of Medical Sciences, Uppsala University, SE-751 05 Uppsala, Sweden.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux ›
questionsmedicales.fr › Techniques d'investigation › Radiométrie › Autoradiographie ›
questionsmedicales.fr › Produits chimiques inorganiques › Composés du fluor › Acide fluorhydrique › Fluorures ›
questionsmedicales.fr › Produits chimiques inorganiques › Isotopes › Radio-isotopes › Radio-isotopes du fluor ›
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Ligands ›
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons ›
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Radiopharmaceutiques ›