3D source tracking and error detection in HDR using two independent scintillator dosimetry systems.
3D source location reconstruction
HDR brachytherapy
in vivo dosimetry
scintillator detector
source tracking
Journal
Medical physics
ISSN: 2473-4209
Titre abrégé: Med Phys
Pays: United States
ID NLM: 0425746
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
22
09
2020
received:
21
06
2020
accepted:
01
11
2020
pubmed:
23
11
2020
medline:
25
5
2021
entrez:
22
11
2020
Statut:
ppublish
Résumé
The aim of this study is to perform three-dimensional (3D) source position reconstruction by combining in vivo dosimetry measurements from two independent detector systems. Time-resolved dosimetry was performed in a water phantom during HDR brachytherapy irradiation with Approximately 4000 source dwell positions were tracked for eight different HDR plans. An intersection of the mPSD torus and the ISD sphere was observed in 77.2% of the dwell positions, assuming no uncertainty in the dose rate determined distance. This increased to 100% if 1σ search regions were added. However, only 73(96)% of the expected dwell positions were found within the intersection band for 1(2) σ uncertainties. The agreement between the source's reconstructed and expected positions was within 3 mm for a range of distances to the source up to 50 mm. The experiments on a HDR prostate plan, showed that by having at least one of the detectors located in the middle of the prostate volume, reduces the measurement deviations considerably compared to scenarios where the detectors were located outside of the prostate volume. The analysis showed a detection probability that, in most cases, is far from the random detection threshold. Errors of 1(2) mm can be detected in ranges of 5-25 (25-50) mm from the source, with a true detection probability rate higher than 80%, while the false probability rate is kept below 20%. By combining two detector responses, we enabled the determination of the absolute source coordinates. The combination of the mPSD and the ISD in vivo dosimetry constitutes a promising alternative for real-time 3D source tracking in HDR brachytherapy.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2095-2107Subventions
Organisme : National Sciences and Engineering Research Council of Canada
ID : 484144-15
Organisme : National Sciences and Engineering Research Council of Canada
ID : RGPIN-2019-05038
Organisme : Canadian Foundation for Innovation
ID : 35633
Organisme : Fonds de Recherche du Quebec - Nature et Technologies
Organisme : Natural Sciences and Engineering Research Council of Canada
ID : 432290
Organisme : Novo Nordisk Foundation
ID : NFF10OC0058756
Informations de copyright
© 2020 American Association of Physicists in Medicine.
Références
Fonseca GP, Podesta M, Bellezzo M, et al. Online pretreatment verification of high-dose rate brachytherapy using an imaging panel. Phys Med Biol. 2017;62:5440.
Williamson JF. Brachytherapy technology and physics practice since 1950: a half-century of progress. Phys Med Biol. 2006;51:R303-R325.
Duan J, Macey DJ, Pareek PN, Brezovich IA. Real-time monitoring and verification of in vivo high dose rate brachytherapy using a pinhole camera. Med Phys. 2001;28:167-173.
Cartwright LE, Suchowerska N, Yin Y, Lambert J, Haque M, McKenzie DR. Dose mapping of the rectal wall during brachytherapy with an array of scintillation dosimeters. Med Phys. 2010;37:2247-2255.
Hardcastle N, Cutajar DL, Metcalfe PE. In vivo real-time rectal wall dosimetry for prostate radiotherapy. Phys Med Biol. 2010;55:3859.
Batič M, Burger J, Cindro V, et al. Verification of high dose rate 192ir source position during brachytherapy treatment. Nucl Instrum Methods Phys Res Sect A. 2010;617:206-208.
Kertzscher G, Andersen CE, Siebert F-A, Nielsen SK, Lindegaard JC, Tanderup K. Identifying afterloading PDR and HDR brachytherapy errors using real-time fiber-coupled Al2o3:C dosimetry and a novel statistical error decision criterion. Radiother Oncol. 2011;100:456-462.
Seymour EL, Downes SJ, Fogarty GB, Izard MA, Metcalfe P. In vivo real-time dosimetric verification in high dose rate prostate brachytherapy. Med Phys. 2011;38:4785-4794.
Therriault-Proulx F, Beddar S, Beaulieu L. On the use of a single-fiber multipoint plastic scintillation detector for 192Ir high-dose-rate brachytherapy. Med Phys. 2013;40:062101.
Smith RL, Taylor ML, McDermott LN, Haworth A, Millar JL, Franich RD. Source position verification and dosimetry in HDR brachytherapy using an EPID. Med Phys. 2013;40:111706.
Kertzscher G, Andersen CE, Tanderup K. Adaptive error detection for HDR/PDR brachytherapy: guidance for decision making during real-time in vivo point dosimetry. Med Phys. 2014;41:052102.
Safavi-Naeini M, Han Z, Alnaghy S, et al. Brachyview, a novel in-body imaging system for hdr prostate brachytherapy: experimental evaluation. Med Phys. 2015;42:7098-7107.
Guiral P, Ribouton J, Jalade P, et al. Design and testing of a phantom and instrumented gynecological applicator based on gan dosimeter for use in high dose rate brachytherapy quality assurance. Med Phys. 2016;43:5240-5251.
Smith RL, Haworth A, Panettieri V, Millar JL, Franich RD. A method for verification of treatment delivery in hdr prostate brachytherapy using a flat panel detector for both imaging and source tracking. Med Phys. 2016;43:2435-2442.
Johansen JG, Rylander S, Buus S, et al. Time-resolved in vivo dosimetry for source tracking in brachytherapy. Brachytherapy. 2018;17:122-132.
Watanabe Y, Muraishi H, Takei H, et al. Automated source tracking with a pinhole imaging system during high-dose-rate brachytherapy treatment. Phys Med Biol. 2018;63:145002.
Linares Rosales HM, Archambault L, Beddar S, Beaulieu L. Dosimetric performance of a multi-point plastic scintillator dosimeter as a tool for real-time source tracking in high dose rate 192 ir brachytherapy. Med Phys. 2020;47:4477-4490.
Rivard MJ, Coursey BM, DeWerd LA, et al. Update of AAPM Task Group No. 43 report: a revised AAPM protocol for brachytherapy dose calculations. Med Phys. 2004;31:633-674.
Hamamatsu Photonics. Hamamatsu PMT H10722 Series. October 2016. https://www.hamamatsu.com/resources/pdf/etd/H10722_TPMO1063E.pdf
Therriault-Proulx F, Beddar S, Briere TM, Archambault L, Beaulieu L. Technical note: removing the stem effect when performing Ir-192 HDR brachytherapy in vivo dosimetry using plastic scintillation detectors: a relevant and necessary step. Med Phys. 2011;38:2176-2179.
Archambault L, Therriault-Proulx F, Beddar S, Beaulieu L. A mathematical formalism for hyperspectral, multipoint plastic scintillation detectors. Phys Med Biol. 2012;57:7133.
Linares Rosales HM, Duguay-Drouin P, Archambault L, Beddar S, Beaulieu L. Optimization of a multipoint plastic scintillator dosimeter for high dose rate brachytherapy. Med Phys. 2019;46:2412-2421.
National Instruments Corporation. National Instruments Multifunction Data Acquisition Device. October 2016. http://sine.ni.com/nips/cds/view/p/lang/en/nid/209154
Kertzscher G, Beddar S. Inorganic scintillator detectors for real-time verification during brachytherapy. J Phys Conf Ser. 2017;847:012036.
Kertzscher G, Beddar S. Inorganic scintillation detectors for 192ir brachytherapy. Phys Med Biol. 2019;64:225018.
Rabiner L. Fundamentals of speech recognition. Fundamentals of speech recognition; 1993.
Andersen CE, Nielsen SK, Lindegaard JC, Tanderup K. Time-resolved in vivo luminescence dosimetry for online error detection in pulsed dose-rate brachytherapy. Med Phys. 2009;36:5033-5043.
Tanderup K, Beddar S, Andersen CE, Kertzscher G, Cygler JE. In vivo dosimetry in brachytherapy. Med Phys. 2013;40:070902.
Hintze JL, Nelson RD. Violin plots: a box plot-density trace synergism. Am Stat. 1998;52:181-184.
Sethi R, Chun Kuo Y, Edraki B, Lerner D, Paik D, Bice W. Real-time doppler ultrasound to identify vessels and guide needle placement for gynecologic interstitial brachytherapy. Brachytherapy. 2018;17:S114-S115.
Fonseca G, Johansen JG, Smith RL, et al. In vivo dosimetry in brachytherapy: requirements and future directions for research, development, and clinical practice. Phys Imaging Radiat Oncol. 2020;16:1-11.