Dynamics of the bacterial gut microbiota during controlled human infection with
Necator americanus
Gut microbiota
controlled human infection
helminth
hookworm
longitudinal
Journal
Gut microbes
ISSN: 1949-0984
Titre abrégé: Gut Microbes
Pays: United States
ID NLM: 101495343
Informations de publication
Date de publication:
09 11 2020
09 11 2020
Historique:
entrez:
23
11
2020
pubmed:
24
11
2020
medline:
1
10
2021
Statut:
ppublish
Résumé
Hookworms are soil-transmitted helminths that use immune-evasive strategies to persist in the human duodenum where they are responsible for anemia and protein loss. Given their location and immune regulatory effects, hookworms likely impact the bacterial microbiota. However, microbiota studies struggle to deconvolute the effect of hookworms from confounders such as coinfections and malnutrition. We thus used an experimental human hookworm infection model to explore temporal changes in the gut microbiota before and during hookworm infection. Volunteers were dermally exposed to cumulative dosages of 50, 100 or 150 L3
Identifiants
pubmed: 33222610
doi: 10.1080/19490976.2020.1840764
pmc: PMC7714523
doi:
Substances chimiques
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1-15Références
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